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Biophysics (Daisuke Inoe) Lab
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A lab that uses in vitro reconstitution to investigate how the cell's structural framework assembles itself.

AboutAbout the lab
Uncovering the self-assembly of the cytoskeleton.
The lab of Associate Professor Daisuke Inoe studies how the cytoskeleton, which controls cell shape, orientation, and movement, assembles itself.
Using in vitro reconstitution systems, the lab investigates the mechanisms of cytoskeletal self-assembly.
The lab also works on protein engineering using DNA nanotechnology and synthetic biology, taking on the design of proteins that can be controlled externally and proteins with new functions.
By combining methods from biology with those from chemistry and engineering, the lab aims to artificially build molecular systems that function like cells (molecular robots).
Key terms
- Cytoskeleton
- A protein-based structure involved in cell shape, orientation, and movement. It includes microtubules and actin
- Motor protein
- A protein that generates movement and transport inside cells, such as kinesin, myosin, and dynein
- DNA origami
- A technique that folds DNA to create nanoscale shapes
ResearchResearch themes
The lab aims to clarify how the cytoskeleton, which controls cell shape, orientation, and movement, assembles itself. By combining methods from biology with those from chemistry and engineering, the lab is trying to artificially build molecular systems that function like cells.
*Illustrative imageSelf-assembly of the cytoskeleton
The lab investigates how the cytoskeleton assembles itself, using in vitro reconstitution systems. The materials studied include cytoskeletal components such as microtubules and actin, and motor proteins such as kinesin.
*Illustrative imageProtein design with DNA and synthetic biology
Based on DNA nanotechnology and synthetic biology, the lab takes on the design of proteins that can be controlled externally and proteins with new functions. The materials studied also include DNA origami.
*Illustrative imageBio-art that shows the molecular world
To visualize the molecular-scale world in an easy-to-understand way, the lab creates bio-art works using 2D/3D computer graphics, VR, and AI technologies. Some of them are open to the public on platforms such as VRChat.
MembersFaculty
- Associate ProfessorDaisuke Inoe
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “DNA tetrahedron” Antony-22 / CC BY-SA 3.0 (cropped)
- Self-assembly of the cytoskeleton: “Microtubules in Primary Mouse Embryonic Fibroblasts” Howard Vindin / CC BY 4.0 (cropped)
- Protein design with DNA and synthetic biology: “DNA Origami Triangular” Matthias A. Fenner / CC BY-SA 4.0 (cropped)
- Bio-art that shows the molecular world: “Molecule Man Sunset” Neil Mercer / CC BY-SA 4.0 (cropped)
- Related lab (Biophysics Lab): “Depth Coded Phalloidin Stained Actin Filaments Cancer Cell” Howard Vindin / CC BY-SA 4.0 (cropped)
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- Related lab (Environmental Chemistry Lab): “EPA GULF BREEZE LABORATORY, CHEMISTRY LAB. A PHYSICAL SCIENCE TECHNICIAN IS EXTRACTING PESTICIDES FROM SEDIMENT SAMPLES - NARA - 546275” William C. Shrout / Public domain (cropped)
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