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Biophysics Lab
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The lab investigates how the cytoskeleton works, aiming to realize molecular robots.
AboutAbout the lab
Controlling the cytoskeleton to build molecular robots.
Associate Professor Daisuke Inoe's lab uses in vitro reconstitution experiments to study how the cytoskeleton, which controls a cell's shape, orientation, and movement, self-assembles.
By combining biological methods for working with biomaterials and chemical and engineering methods for modifying them, the lab aims to artificially create molecular robots that function like cells.
To make the molecular-scale world easy to see and understand, the lab also creates bioart works using 2D/3D CG, VR, and AI.
On Kyushu University's researcher information page, the lab's website is introduced as the Cytoskeletal Architecture and Bio-Self-Assembly lab.
Key terms
- cytoskeleton
- The structures that control a cell's shape, orientation, and movement. This lab works with microtubules, actin, and FtsZ
- biomolecular motor
- Proteins such as kinesin, myosin, and dynein. This lab uses them as research materials
- molecular robot
- A molecular system that functions like a cell. The lab aims to create one artificially
ResearchResearch themes
The lab aims to gain free control over the cytoskeleton, the designer of the cell, and uses in vitro reconstitution experiments to study how the cytoskeleton self-assembles. It also works on protein engineering using DNA nanotechnology and synthetic biology, and on bioart that makes the molecular world visible and understandable.
*Illustrative imageHow the cytoskeleton self-assembles
Using in vitro reconstitution experiments, the lab studies the mechanisms of self-assembly, in which the cytoskeleton, which controls a cell's shape, orientation, and movement, builds itself up. The materials include cytoskeletal components such as microtubules, actin, and FtsZ, and biomolecular motors such as kinesin, myosin, and dynein.
*Illustrative imageProtein engineering with DNA and synthetic biology
This research applies protein engineering using DNA nanotechnology and synthetic biology. The lab takes on the challenge of designing proteins that can be controlled externally and proteins with new functions.
*Illustrative imageBioart that shows the molecular world
To visualize the molecular-scale world in an easy-to-understand way, the lab creates works using 2D/3D CG, VR, and AI. Some of them are open to the public on platforms such as VRChat.
MembersFaculty
- Associate ProfessorDaisuke Inoe
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Depth Coded Phalloidin Stained Actin Filaments Cancer Cell” Howard Vindin / CC BY-SA 4.0 (cropped)
- How the cytoskeleton self-assembles: “F-actin filaments in cardiomyocytes” Ps1415 / CC BY-SA 4.0 (cropped)
- Protein engineering with DNA and synthetic biology: “Loading DNA sample into to agarose gel electrophoresis” 26Isabella, Eijkman Institute for Molecular Biology, Indonesia / CC BY 4.0 (cropped)
- Bioart that shows the molecular world: “Glass ochem” Purpy Pupple / CC BY-SA 3.0 (cropped)
- Related lab (Biophysics (Daisuke Inoe) Lab): “DNA tetrahedron” Antony-22 / CC BY-SA 3.0 (cropped)
- Related lab (Environmental Chemistry Lab): “Mass-Spectrometer-MASPEC---Europa-Clipper” NASA / Public domain (cropped)
- Related lab (Environmental Chemistry Lab): “EPA GULF BREEZE LABORATORY, CHEMISTRY LAB. A PHYSICAL SCIENCE TECHNICIAN IS EXTRACTING PESTICIDES FROM SEDIMENT SAMPLES - NARA - 546275” William C. Shrout / Public domain (cropped)
- Related lab (Architectural Materials Lab): “Weathered barn wood with worm holes” Titus Tscharntke / Public domain (cropped)
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