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Reproductive Pathophysiology Lab
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A lab that cares for women throughout their lives through reproductive endocrinology, perinatal medicine, and gynecologic oncology.
AboutAbout the lab
A clinical department caring for women's whole lives.
The Reproductive Pathophysiology Lab is the Department of Obstetrics and Gynecology of the Faculty of Medical Sciences at Kyushu University, and carries out research and clinical care in three research groups: reproductive endocrinology, perinatal medicine, and gynecologic oncology.
The reproductive endocrinology group investigates the mechanisms of diseases caused by various disturbances of the endocrine environment, and aims to develop new diagnostic methods and minimally invasive treatments.
The perinatal medicine group investigates the development and differentiation of villous trophoblasts, fetal behavioral science, and the pathophysiology of pregnancy complications, and aims to develop new clinical care and management methods for abnormal pregnancies.
The gynecologic oncology group analyzes cases from its own institution while also taking part in multi-institutional studies, clarifies the molecular mechanisms of cancer development and characteristics, and works on developing diagnostic and treatment methods.
Key terms
- Perinatal period
- The period from pregnancy through the time around childbirth
- Villous trophoblast
- The cells that form the villi of the placenta
- Primordial follicle
- A follicle in the ovary that gives rise to all other follicles. Its number does not increase after birth
ResearchResearch themes
The Reproductive Pathophysiology Lab studies the mechanisms involved in women's diseases and pregnancy through three groups: reproductive endocrinology, perinatal medicine, and gynecologic oncology. It investigates diseases caused by a disturbed endocrine environment, pregnancy complications, and the molecular mechanisms of cancer development and characteristics, with the aim of developing new diagnosis and treatment.
*Illustrative imageEndometrial Aging and Infertility
Besides aging of the egg, functional impairment caused by aging of the endometrium is thought to be a cause of age-related infertility and miscarriage. The lab studies the genetic changes that bring about aging and the cytokines that cause inflammation, with the aim of developing new treatments for infertility.
*Illustrative imageHow Primordial Follicles Are Maintained
Primordial follicles do not increase after birth, and once menarche arrives, a portion of them is activated with each menstrual cycle, so their number gradually declines. The lab aims to clarify the mechanisms involved in maintaining them and to develop ways to prevent premature menopause.
*Illustrative imageA Substance That Supports Implantation and Maintenance of Pregnancy
For pregnancy to occur, the mother's body needs a mechanism that keeps it from rejecting the fetus as a foreign object. By analyzing the endometrium, blood, and placenta, the lab has clarified the role of cholesterol sulfate in supporting implantation and the maintenance of pregnancy, and aims to develop new diagnostic methods and treatments for infertility, recurrent pregnancy loss, and habitual miscarriage.
MembersFaculty
The members of the Reproductive Pathophysiology Lab consist of faculty, clinical staff physicians, and project faculty members.As of 2026
- Associate ProfessorHideaki Yahata
- Project Associate ProfessorKazuo Asanoma
- Concurrent LecturerIchiro Onoyama
- LecturerHiroshi Yagi
- Assistant ProfessorSaki Kido
- Assistant ProfessorShoji Maenohara
- Assistant ProfessorHidehiko Kawamura
- Concurrent LecturerKeisuke Kodama
- Assistant ProfessorAtsuhiko Sakai
- Assistant ProfessorHiroshi Tomonobu
- Assistant ProfessorKeiko Kawamura
- Project Assistant ProfessorNorio Hamada
- Assistant ProfessorRyo Seikiba
- Clinical LecturerKazuhisa Hachisuka
- Assistant ProfessorKazunari Nakahara
- Assistant ProfessorYoshihiro Katayama
- Assistant ProfessorKenichiro Hirotani
- ProfessorSeiichi Morokuma
- Associate ProfessorKenzo Sonoda
- Assistant ProfessorTakeshi Murakami
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Midwife check-up” Ricmart 01 / CC BY-SA 4.0 (cropped)
- Endometrial Aging and Infertility: “Uterus (endometrium)” Jpogi at Wikipedia / Public domain (cropped)
- How Primordial Follicles Are Maintained: “Graafian Follicle, Human Ovary ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- A Substance That Supports Implantation and Maintenance of Pregnancy: “Anatomy and physiology of animals Development & implantation of the embryo” Original uploader was Sunshineconnelly at en.wikibooks / CC BY 3.0 (cropped)
- Related lab (Growth and Developmental Medicine Lab): “Itzhak Levy 2” דוברות מרכז שניידר לרפואת ילדים בישראל / CC BY-SA 4.0 (cropped)
- Related lab (Disease Information Research Lab): “Respiratory system - Olfactory bulb 1 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (Medicine and Bioregulatory Science Lab): “Insulin struct” User:AtikaAtikawa / CC BY-SA 4.0 (cropped)
- Related lab (Neuropsychiatry Lab): “Rat primary cortical neuron culture, 3D reconstruction ( )” ZEISS Microscopy from Germany / CC BY 2.0 (cropped)
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