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Precision Medicine Lab
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A precision medicine lab that investigates why cancers are hard to treat, using genomic information and other data.

AboutAbout the lab
Bridging basic research to clinical practice
The Precision Medicine Lab studies medicine that uses data such as genomic information to provide each patient with the cancer prevention and treatment best suited to them.
The lab first aims to build the foundations for clinical care, education, and research in "cancer precision medicine," and in the future to extend the field to other areas such as lifestyle-related diseases.
The department's three main themes are to clarify the diversity of cancer and develop new treatments, to establish prevention methods based on individual genomic information, and to build a clinical system in which new cancer drugs can be used.
It was established in March 2020 as a unit within the Department of Internal Medicine, Division of Clinical Medicine.
Key terms
- Gene panel testing
- A test that analyzes multiple cancer-related genes together to find genetic abnormalities in cancer tissue
- CRISPR/Cas9
- A gene-editing technology that rewrites genes at targeted sites. It is also used in comprehensive experiments that target all genes
- Hematopoietic stem cells
- Cells that give rise to all blood cells. They produce blood cells through self-renewal and differentiation
NewsLab news
A paper searching for therapeutic targets in TP53-mutated leukemia was published in the journal Blood
A paper identifying genes involved in sensitivity to XPO1 inhibitors was published in the journal Leukemia
A paper investigating the mechanism of steroid resistance in leukemia cells was published in the journal Blood Neoplasia
ResearchResearch themes
Cancer is hard to cure because of genetic abnormalities within cells and within individual patients. Through genomic-information-based diagnosis, searches for therapeutic targets with CRISPR/Cas9, single-cell analysis, and other approaches, the lab aims to develop medicine that overcomes the treatment resistance of cancer.
*Illustrative imageGene panel testing for blood cancers
The lab is developing DISCAVar, a gene panel test specialized for blood cancers, in collaboration with the Hematology Lab of the First Department of Internal Medicine at Kyushu University and the Department of Gene and Cell Therapy at Kyushu University Hospital. It conducts research on precision cancer medicine at Kyushu University Hospital and affiliated facilities.
*Illustrative imageComprehensive search for cancer therapeutic targets
Using CRISPR/Cas9 to target all protein-coding genes, the lab examines their effects on cancer cell growth, cell death, and other processes. Using leukemia cell lines with different genetic backgrounds, it works on developing new treatments and drugs for refractory leukemia.
*Illustrative imageSingle-cell research on cancer
The lab analyzes cancer cells and the normal cells around them one by one, examining gene mutations and the expression of mRNA and proteins. Together with the First Department of Internal Medicine and the Department of Gene and Cell Therapy at Kyushu University, it is trying to clarify how the immune system is rebuilt after hematopoietic stem cell transplantation and how leukemia relapses.
*Illustrative imageMechanisms that control blood cell differentiation
The lab studies the molecular mechanisms that control differentiation and proliferation as hematopoietic stem cells give rise to blood cells. It aims to apply the findings to treatment not only of blood cancers but also of collagen diseases, chronic inflammatory diseases, and cardiovascular diseases.
MembersFaculty
The members of the Precision Medicine Lab consist of faculty, joint researchers, and doctoral and master's students.As of 2026
- ProfessorTakahiro Maeda
- Assistant ProfessorShigeki Hirabayashi
- Assistant ProfessorYuichiro Semba
- Assistant ProfessorKiyoko Miyata
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Chronic lymphocytic leukemia” Mary Ann Thompson (VashiDonsk at en.wikipedia) / CC BY-SA 3.0 (cropped)
- Gene panel testing for blood cancers: “Hairy cell leukemia smear” Paulo Henrique Orlandi Mourao / CC BY-SA 3.0 (cropped)
- Comprehensive search for cancer therapeutic targets: “Smartphone colorimetry – 96-well microplate with serial dilutions of coloured solutions” Mdc-science / CC BY-SA 4.0 (cropped)
- Single-cell research on cancer: “Fluidigm C1 Single-Cell Auto Prep system” Konrad Förstner / CC BY 2.0 (cropped)
- Mechanisms that control blood cell differentiation: “Trilineage hematopoiesis (original)” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Related lab (Multi-omics Analysis Lab): “30nm Chromatin Structures” Zephyris at English Wikipedia / CC BY-SA 3.0 (cropped)
- Related lab (Morphology and Functional Pathology Lab): “Smooth muscle (histology slide)” Juan Carlos Fonseca Mata / CC BY-SA 4.0 (cropped)
- Related lab (Biochemistry Lab): “A Pathway to Protocells on Titan – Animations (SVS -Cell-Membrane-Thumbnail)” NASA's Scientific Visualization Studio - NASA Goddard / Public domain (cropped)
- Related lab (Cell Physiology Lab): “Epithelioid cells of mice in the cell culture” ArkhipovSergey / CC BY-SA 4.0 (cropped)
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