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Eukaryotic Cell Microbiology Lab
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A lab that investigates the mechanisms of sexual reproduction and cell division in methylotrophic yeast.
AboutAbout the lab
Uncovering yeast sexual reproduction and cell division at the molecular level.
The Eukaryotic Cell Microbiology Lab uses methylotrophic yeast to study the mechanisms that control cell division and sexual reproduction.
Yeasts are industrially useful microorganisms, and research on them as model organisms has contributed greatly to understanding the cell cycle, protein transport, and more.
The lab works with Ogataea polymorpha, which is evolutionarily distant from the well-studied budding yeast.
It studies how this yeast switches its mating type and how it controls the progression of cell division.
Key terms
- Methylotrophic yeast
- Yeast that can use methanol as a nutrient source. This lab studies Ogataea polymorpha.
- Mating type
- The distinction between a-type and α-type cells in yeast. Cells of the a type and the α type mate with each other.
- Spindle pole body
- A structure inside yeast cells that serves as the center where microtubules form. It is functionally homologous to the centrosome in animals.
ResearchResearch themes
The lab studies the methylotrophic yeast Ogataea polymorpha, which is evolutionarily distant from budding yeast, to clarify the molecular mechanisms that control cell division and sexual reproduction. There are at least 1,000 yeast species, and studying phylogenetically distant species is expected to deepen our understanding of yeast characteristics and evolution.
*Illustrative imageSexual reproduction in methylotrophic yeast
This yeast normally proliferates as a haploid and mates to form spores only under nutrient starvation. It is known to switch its mating type during starvation through a new molecular mechanism called the flip-flop type, and the lab is working to clarify how this mechanism works.
*Illustrative imageControl of yeast cell division
In yeast, the spindle pole body serves as the center where microtubules are formed and distributes the nucleus to the daughter cells. In this yeast, the duplication cycle of the spindle pole body is known to be under distinctive regulation, and the lab is investigating whether this affects the progression of mitosis.
MembersFaculty
The Eukaryotic Cell Microbiology Lab consists of faculty members only.
- Associate ProfessorHiromi Maekawa
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “ATCC strains of Candida albicans, Pichia kudriavzevii, and Candida parapsilosis on Chromagar after 7 days of incubation” Ajay Kumar Chaurasiya / CC BY 4.0 (cropped)
- Sexual reproduction in methylotrophic yeast: “Yeast Cells in LPCB Tease Mount” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Control of yeast cell division: “Yeast Cells in Wet Mount Microscopy of Culture” Ajay Kumar Chaurasiya / CC0 (cropped)
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