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Microtubule Dynamics Lab
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The lab studies how microtubules move in yeast and filamentous fungi.
AboutAbout the lab
Exploring microtubule dynamics in yeast and filamentous fungi
The Microtubule Dynamics Lab studies the behavior of microtubules, which are involved in cell division and intracellular transport, using yeast and filamentous fungi.
Microtubules are assembled from the protein tubulin and, using GTP as an energy source, show dynamic instability: they switch between phases of growth and sudden shrinkage.
It is known that microtubules made from yeast tubulin move differently from those made from mammalian tubulin, and the lab investigates how this difference arises from small differences in amino acids.
The lab combines biochemical methods with in vitro analysis using microscopy to work at the cellular and molecular levels.
Key terms
- Microtubule
- A structure formed by the assembly of the protein tubulin. It functions in cell division and intracellular transport.
- Dynamic instability
- A property of microtubules in which they switch between phases of growth and sudden shrinkage. It is driven by energy from GTP.
- Kinesin
- A type of molecular motor protein that moves along microtubules.
ResearchResearch themes
Microtubules are structures that function in cell division and intracellular transport in eukaryotes. The lab studies microtubule dynamics by combining research using cells such as yeast with in vitro analysis using purified tubulin.
Dynamics of tubulin in filamentous fungi
Many filamentous fungi cause disease in animals and plants, and tubulin is also a target of fungicides, but little is known about tubulin in filamentous fungi. The lab is exploring new methods for expression and purification, and is examining the action of fungicides in vitro.
*Illustrative imageProteins that act on microtubules
The lab studies molecular motor proteins such as kinesin that move along microtubules, as well as various microtubule-binding proteins that regulate microtubule dynamics.
MembersFaculty
- ProfessorDouglas Drummond
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Fungi - Hyphae - (lactophenol cotton blue dye)” Juan Carlos Fonseca Mata / CC BY-SA 4.0 (cropped)
- Proteins that act on microtubules: “Cytoskeleton - Microtubule -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (Biological Protection and Management Lab): “APHIS-Moore Air Base in Texas-Plant Protection and Quarantine Science and Technology Insect Management and Molecular Diagnostics Laboratory (20230621-CDP-APHIS-0277)” USDAgov / Public domain (cropped)
- Related lab (Eukaryotic Cell Microbiology Lab): “ATCC strains of Candida albicans, Pichia kudriavzevii, and Candida parapsilosis on Chromagar after 7 days of incubation” Ajay Kumar Chaurasiya / CC BY 4.0 (cropped)
- Related lab (Animal Nutritional Physiology Lab): “Broiler chicks around a week old” Shadow Ayush / CC BY-SA 4.0 (cropped)
- Related lab (Tropical Crop Science and Environment Lab): “Portrait of an ant, profile view” Retro Lenses / CC BY 4.0 (cropped)
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