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Aquatic Developmental Toxicology Lab
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A lab that uses fish and cells to study developmental diseases and osmoregulation.

AboutAbout the lab
Exploring developmental diseases through fish and cells
The Aquatic Developmental Toxicology Lab studies the mechanisms of diseases related to development, as well as osmoregulation in cells and fish.
Its research focuses on disease mechanisms, the function of deubiquitinating enzymes, osmoregulation, and developmental toxicity.
The lab works with cultured cells and small fish such as zebrafish and medaka.
Combining a variety of molecular biology techniques with omics technologies, the lab tackles questions in biology.
Key terms
- Cleft lip and palate
- A type of abnormality in the formation of the face. Gene mutations are known to be one of its causes.
- Osmoregulation
- The function of maintaining a cell's state, for example by restoring cell volume, when external osmotic pressure changes.
- Omics technologies
- Analytical methods that comprehensively examine the molecules in a living organism all at once.
ResearchResearch themes
The lab studies the mechanisms of diseases related to development, and how cells and fish respond to changes in external osmotic pressure. Using cultured cells and small fish such as zebrafish and medaka, it analyzes them with molecular biology techniques and omics technologies.
*Illustrative imageMechanisms of developmental diseases
Using cultured cells and animal models, the lab studies developmental diseases, focusing on craniofacial malformations. Gene mutations are known to cause cleft lip and palate, and by understanding the pathology, the lab aims to identify candidate gene therapies and small molecules for treatment.
*Illustrative imageOsmoregulation in fish
When external osmotic pressure changes, cells maintain their state by restoring their volume and altering the structure of their cytoskeleton. The lab studies this mechanism, which is especially important in the gill epithelium of fish, at the molecular level using multiple omics technologies.
MembersFaculty
- Associate ProfessorWilliam Ka Fai Tse
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Danio rerio lab right” Pogrebnoj-Alexandroff / CC BY-SA 3.0 (cropped)
- Mechanisms of developmental diseases: “Zebrafish embryo” Nikita Tsyba in cooperation with Azamat Bashabayev / CC BY-SA 4.0 (cropped)
- Osmoregulation in fish: “Fish dykes, Luce estuary - geograph.org.uk - 461729” David Baird / CC BY-SA 2.0 (cropped)
- Related lab (細胞制御工学): “Epithelioid cells and macrophages in cell culture” ArkhipovSergey / CC BY-SA 4.0 (cropped)
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