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Photophysical Chemistry Lab
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The lab develops methods for observing cells and biological tissues by using the interaction between light and molecules.

AboutAbout the lab
Seeing cells and tissues through molecular fingerprints.
The Photophysical Chemistry Lab studies new ways to examine cells and biological tissues using the interaction between light and molecules, in particular a phenomenon called nonlinear Raman scattering.
The lab is developing new imaging methods for cells and biological tissues based on "molecular fingerprints."
Medical applications such as pathological diagnosis and disease diagnosis are one of the lab's research targets.
The lab also works on developing methods that combine optical measurement with information processing.
Key terms
- Nonlinear Raman scattering
- A nonlinear optical phenomenon that arises from the interaction between light and molecules. It is used as a means of reading molecular fingerprints.
- Molecular fingerprint
- A characteristic that serves as a clue for identifying a molecule. The lab reads it from within cells and tissues using nonlinear Raman scattering.
ResearchResearch themes
The lab develops new methods for observing cells and biological tissues using the interaction between light and molecules. In particular, it uses nonlinear Raman scattering, and one of its research targets is medical applications such as pathological diagnosis and disease diagnosis.
*Illustrative imageObserving Cells and Tissues with Raman Scattering
Using the interaction between light and molecules, in particular nonlinear Raman scattering, the lab develops new methods that visualize cells and biological tissues through their "molecular fingerprints." Medical applications such as pathological diagnosis and disease diagnosis are one of its targets.
*Illustrative imageMethods Integrating Optical Measurement and Information Processing
The lab develops methods that integrate optical measurement with information processing to efficiently explore previously unexplored time, space, and energy regimes. Specific examples are the creation of new useful strains by combining large-scale cell measurement and sorting with genetic mutations, and the elucidation of material fracture processes through fast, long-duration spectral measurement.
*Illustrative imageVisualizing Molecules in the Mouse Brain
The lab aims to make visible the molecules in the mouse brain, which is important for understanding neuroscience. It develops highly sensitive molecular imaging based on physical chemistry.
*Illustrative imageLabel-Free Microscopic Imaging
The lab works on developing microscopic imaging methods for observing living organisms without labels. Super-resolution microscopy and optical microscopy are listed as keywords of the research.
MembersFaculty
- ProfessorKotaro Hiramatsu
- Assistant ProfessorRyosuke Oketani
- Assistant ProfessorRyo Nishiyama
- Assistant ProfessorYusuke Murakami
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “AFM-Raman integration” AAMonitor96 / CC BY-SA 3.0 (cropped)
- Observing Cells and Tissues with Raman Scattering: “InVia Raman microscope - March 2008” theterrifictc / CC BY-SA 2.0 (cropped)
- Methods Integrating Optical Measurement and Information Processing: “Yi Xue Computational Optics for Biomedical Imaging Lab ( )” UC Davis College of Engineering / CC BY 2.0 (cropped)
- Visualizing Molecules in the Mouse Brain: “Mouse Brain” J dotter / CC BY-SA 4.0 (cropped)
- Label-Free Microscopic Imaging: “HEK (Human Embryonic Kidney) cells, phase contrast microscopy with ZEISS Celldiscoverer )” ZEISS Microscopy from Germany / CC BY 2.0 (cropped)
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- Related lab (有機反応化学研究室): “Crystallisation? Reaction? Don't remember ( )” Максим Фомич / CC BY 2.0 (cropped)
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