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Biomolecular Functional Chemistry Lab
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The lab searches for small molecules that bind RNA, aiming at drug discovery and control of biological reactions.
AboutAbout the lab
Aiming for small-molecule drug discovery that targets RNA.
The Biomolecular Functional Chemistry Lab searches for and develops small-molecule compounds that bind to RNA, with the aim of RNA-targeted drug discovery.
RNA is attracting attention as a next-generation drug target because of its diverse functions and its links to disease.
In addition to searching for small-molecule compounds that can freely manipulate the structure and function of RNA, the lab works on molecular design using information science and machine learning.
The lab also conducts applied research on using small-molecule compounds to control intracellular biological reactions involving nucleic acids such as RNA and DNA.
Key terms
- RNA
- Ribonucleic acid. A type of nucleic acid alongside DNA, and a biomolecule with a variety of functions. This lab targets it for drug discovery
- Small-molecule compound
- A compound with a low molecular weight. This lab searches for and develops them as substances that manipulate the structure and function of RNA
- Cheminformatics
- A field that handles data on chemical compounds using methods from information science. This lab applies it to research targeting RNA
ResearchResearch themes
Aiming for small-molecule drug discovery that targets RNA, the lab searches for and develops small-molecule compounds that can freely manipulate the structure and function of RNA. It also works on the molecular design of small-molecule compounds using information science and machine learning, as well as on RNA-targeted cheminformatics.
*Illustrative imageDiscovery and applications of small molecules that bind RNA
The lab searches for and develops small molecules that bind to RNA, and aims to apply them to regulating and controlling biochemical reactions and biological phenomena involving nucleic acids.
*Illustrative imageSearching for RNA motifs that small molecules bind to
The lab is developing methods to find the parts of RNA (RNA motifs) that small molecules can bind to. By analyzing large-scale data on binding pairs of small molecules and RNA, it aims to establish guidelines for molecular design and to build models that predict such pairs.
*Illustrative imageAnalysis of complexes of RNA and small molecules
The lab analyzes complexes of RNA and small molecules, working to clarify how the two interact.
MembersFaculty
- Associate ProfessorAsako Murata
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Pipette (NIH BioArt 408)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Discovery and applications of small molecules that bind RNA: “Types of RNA” Christinelmiller / CC BY-SA 4.0 (cropped)
- Searching for RNA motifs that small molecules bind to: “Consensus secondary structure of the Influenza Pseudoknot family of RNA motifs” Jebus989 / CC BY-SA 3.0 (cropped)
- Analysis of complexes of RNA and small molecules: “Structure of the human RNA exosome - Exosome complex component RRP42 - 2NN6” Vorlaender, M.K., Khatter, H., Wetzel, R., Hagen, W.J.H., Mueller, C.W. / CC0 (cropped)
- Related lab (機能分子工学研究室): “Liquid Crystal” KarlGaff / CC BY 4.0 (cropped)
- Related lab (先進ナノマテリアル科学研究室): “Neon atoms between graphene sheets ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- Related lab (計算材料科学研究室): “Formaldehyde Molecular Orbitals” ChiralJon / CC BY 2.0 (cropped)
- Related lab (ナノ材料・デバイス科学研究室): “Transmission electron microscope (Morgagni 268D) 4pl” Pleple2000 / CC BY-SA 3.0 (cropped)
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