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Biomaterials and Medical Engineering Lab
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A lab that takes on the reconstruction and preservation of organs using cell and material technologies.
AboutAbout the lab
Exploring technologies to reconstruct and preserve organs
The Biomaterials and Medical Engineering Lab focuses mainly on the liver, studying how to artificially rebuild organs and how to preserve cells and organs.
In organ engineering, the lab uses decellularization, a technique that removes only the cells from tissue, to obtain an organ template and uses it as a scaffold.
The lab also works on research involving microfabrication, such as scaffold materials on which cells grow and carriers that deliver drugs through the skin.
On the lab's website, it is also introduced under the name "Ijima Lab."
Key terms
- Decellularization
- A technique that removes only the cells from tissue while leaving the tissue structure and the components surrounding the cells. It makes it possible to obtain an organ template.
- Spheroid
- A spherical cell aggregate formed by cells gathering together.
- Cryoprotectant
- An agent used when freezing cells for preservation to prevent damage to cells and tissue caused by ice crystals.
- Growth factor
- A molecule that regulates cell functions such as proliferation and differentiation.
NewsLab news
A master's student won an Excellent Poster Award at the 63rd Joint Kyushu Conference of Chemistry-Related Branches
A master's student won the Student Excellent Presentation Award (oral presentation) from the Kyushu Branch of the Society of Chemical Engineers, Japan
A student won the Best Poster Award at the 9th SKY Symposium
A doctoral student won the Student Excellent Presentation Award (oral presentation) at the Annual Meeting of the Society for Biotechnology, Japan
ResearchResearch themes
This lab works on research to artificially rebuild organs, centered on the liver. Its research rests on three pillars: reconstruction of organs, preservation of cells and tissues, and microfabrication for scaffold materials and drug carriers.
*Illustrative imageOrgan Engineering through Cell Self-Assembly
The lab controls cell scaffolds and the microculture environment to draw out the self-assembly ability that cells inherently have, exploring ways to build three-dimensional tissues and organs both inside and outside the body. It also builds liver tissue using spherical cell aggregates (spheroids).
*Illustrative imageBuilding Livers on Decellularized Liver Scaffolds
A shortage of donors has long been a problem in liver transplantation. The lab therefore uses decellularized livers as organ templates, and works on methods for placing cells in them and on developing systems to evaluate the liver function of recellularized livers into which cells have been injected.
*Illustrative imagePreservation Technologies for Cells and Organs
The lab studies methods to preserve hepatocytes and livers, which are difficult to preserve, while maintaining their shape and properties. For cells, it develops cryoprotectants; for organs, it builds perfusion systems that deliver oxygen and cryoprotectants throughout the whole organ.
*Illustrative imageNanofiber Scaffolds for Tissue Regeneration
Focusing on scaffolds and growth factors for tissue engineering, the lab develops scaffold materials that can immobilize growth factors. Building on nanofiber scaffolds made by electrospinning, it develops artificial nerves, artificial blood vessels, and more.
MembersFaculty
The lab's members consist of faculty, academic researchers, doctoral, master's, and undergraduate students, and research students.As of 2026
- ProfessorHiroyuki Ijima
- Associate ProfessorYusuke Sakai
- Associate ProfessorTatsuto Kageyama
- Assistant ProfessorYasuhiro Ikegami
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cell culture flat flasks-set” Lilly_M / CC BY-SA 3.0 (cropped)
- Organ Engineering through Cell Self-Assembly: “Organoid (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Building Livers on Decellularized Liver Scaffolds: “3D Medical Animation liver parts” https://www.scientificanimations.com / CC BY-SA 4.0 (cropped)
- Preservation Technologies for Cells and Organs: “Liquid nitrogen storage vessel” Karbohut / CC BY-SA 4.0 (cropped)
- Nanofiber Scaffolds for Tissue Regeneration: “Electronspun Nanofibers April 2023” Deander4 / CC BY-SA 4.0 (cropped)
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