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Biochemical Engineering Lab
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A lab that designs biotechnology, from genes to cells, tissues, and biopharmaceutical production.
AboutAbout the lab
Understanding life to design the future.
The Biochemical Engineering Lab (Kamihira Lab) studies life phenomena at every level, from genes to cells, tissues and organs, and whole organisms, by analyzing them and reconstructing them artificially.
The lab develops new biotechnologies, aiming to design and build the mechanisms of living systems and turn them into usable technologies.
Its research spans the design of information processing inside cells, the construction of tissues that resemble living bodies, the production of biopharmaceuticals, and AI-based evaluation of cells and tissues.
On the lab's website, it is introduced under the name "Kamihira Lab."
Key terms
- Biopharmaceuticals
- Biopharmaceuticals: drugs made mainly of proteins. They are often produced by culturing genetically engineered animal cells.
- CHO cells
- CHO cells: cells derived from the ovary of the Chinese hamster. They are used to produce biopharmaceuticals.
- Living bioreactor
- Living bioreactor: a system that uses genetically modified animals or cells to make pharmaceutical proteins.
NewsLab news
A student receives an Excellent Poster Award at the 63rd Joint Kyushu Convention of the Chemical Societies' Branches
A student receives a Poster Award at the JAACT International Meeting (JAACT2025 Osaka) of the Japanese Association for Animal Cell Technology
A student receives a Student Excellent Presentation Award at the 76th Annual Meeting of the Society for Biotechnology, Japan
Assistant Professor Nana Shirakigawa receives the 3rd Young Researcher Award in Biotechnology from the Society for Biotechnology, Japan
A student receives an Excellent Student Presentation Award at the 61st Joint Kyushu Convention of the Chemical Societies' Branches
ResearchResearch themes
This lab studies life phenomena from genes to cells, tissues and organs, and whole organisms. It analyzes them and reconstructs them artificially, aiming to create new biotechnologies. Its current research is organized into four areas: synthetic biology, cell and tissue engineering, biopharmaceutical production, and AI and biotechnology.
*Illustrative imageDesigning information processing inside cells
Using gene expression control, RNA sensing, viral vectors, and recombinase enzymes, the lab redesigns information processing inside cells. It also works on techniques for introducing genes into selected cell types and gene sequences, and for increasing the number of gene copies on chromosomes.
*Illustrative imageBuilding cells and tissues that resemble living bodies
Through cell patterning, three-dimensional tissue construction, differentiation of pluripotent stem cells into functional cells, and cell encapsulation and culture techniques, the lab builds tissue systems with functions and structures close to those of living bodies. It advances regenerative medical engineering that leads to artificial organs and transplantation medicine.
*Illustrative imageNew ways to produce biopharmaceuticals
Using CHO cells and genetically modified organisms, the lab develops new production platforms for high-yield, high-quality biopharmaceuticals. It also studies techniques that use transgenic birds as living bioreactors to produce pharmaceutical proteins inside eggs.
*Illustrative imageMeasuring the state of cells and tissues with AI
By bringing image analysis, machine learning, and time-series analysis into biotechnology, the lab expresses the state, movement, and function of cells and tissues as numerical values for study. It visualizes as data the changes that are hard to capture through morphological evaluation by the human eye, and uses them to support decisions in research and development.
MembersFaculty
The members of the Biochemical Engineering Lab consist of faculty, doctoral, master's, and undergraduate students, technical staff, and administrative staff.As of 2026
- ProfessorMasamichi Kamihira
- Associate ProfessorYoshinori Kawabe
- Associate ProfessorHiroshi Mizumoto
- Assistant ProfessorNana Shirakigawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Synthetic Biology Costa Rican Beach” MattWildCat / CC BY 4.0 (cropped)
- Designing information processing inside cells: “Synthetic Biology Research at NASA Ames” Alexander van Dijk from San Francisco, United States / CC BY 2.0 (cropped)
- Building cells and tissues that resemble living bodies: “Cell on 2D Monolayer vs. 3D Hydrogel with RGD” Lisa Zlanino / CC BY-SA 4.0 (cropped)
- New ways to produce biopharmaceuticals: “BTEC Bioreactors” RickLawless (talk) (Uploads) / CC BY 3.0 (cropped)
- Measuring the state of cells and tissues with AI: “Fluorescence microscopy of the oral cancer cells” Korinna / CC BY 4.0 (cropped)
- Related lab (生物機能材料工学研究室): “Propel Segmented Flow Chemistry System” Jankhughes / CC BY-SA 3.0 (cropped)
- Related lab (生体材料・医用工学研究室): “Cell culture flat flasks-set” Lilly_M / CC BY-SA 3.0 (cropped)
- Related lab (熱プロセス工学研究室): “Peru - Lares Trek 043 - potatoes laid out for freeze-drying ( )” McKay Savage from London, UK / CC BY 2.0 (cropped)
- Related lab (流体プロセス工学研究室): “Plasma torch auxiliary heating in electric arc furnace British Steel 1985” European Coal and Steel Community / CC BY-SA 4.0 (cropped)
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