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610 labs · 149 student voices
Tomoaki Matsuura, Professor
1 student voices
The Matsuura Lab combines the parts that make up living organisms to build cell-free molecular systems specialized for specific functions. The lab then uses these cell-free molecular systems to evolve proteins and the molecular systems themselves. Through this work, the lab aims to clarify the properties of protocells, which are thought to have existed at the very beginning of life. At the same time, the lab also works on assembling molecules and molecular systems that can contribute to practical applications.
Hideki Taguchi, Professor
1 student voices
The Taguchi Lab studies the 'life of a protein': how proteins are born, take shape, and are broken down inside cells. Proteins are chains of amino acids, and they function only after folding into a defined three-dimensional structure. The lab investigates molecular chaperones, which assist folding, and the behavior of nascent chains that are still being synthesized on the ribosome. Aggregates formed when folding fails, such as amyloids and prions, are also objects of study.
Nobuhiro Hayashi, Professor
1 student voices
The Hayashi Lab regards life as a system made of proteins and conducts research focused on proteins. This is because the lab holds that the properties and state of a cell are determined by the types, amounts, and states of the proteins in it. The lab aims to put proteomics, a technology for analyzing proteins collectively, into practical use and apply it to diagnosis and treatment. It also works on developing artificial antibodies based on a new concept.
Toshiaki Fukui, Professor
1 student voices
Fukui Lab studies biotechnology, aiming to understand and make use of the fascinating abilities of microorganisms. Most organisms live at around 30°C, but microorganisms called hyperthermophiles thrive at temperatures of 90°C or higher. Some microbes also store polyesters rather than polysaccharides inside their cells, and these polyesters are expected to serve as materials to replace petroleum-based plastics. With these two types of microbes as its main subjects, the lab aims to investigate the abilities of tiny microorganisms and put them to practical use.
Nikaido Masato, Professor
1 student voices
Nikaido Lab studies, at the level of DNA, the mechanisms of adaptive evolution, by which organisms change their form and way of life to suit their environments. Organisms from distantly related lineages sometimes adapt to similar environments and acquire strikingly similar forms and ecology, a phenomenon called parallel evolution. Using subjects such as cichlids living in East African lakes and mammals whose body hair has turned into spines, the lab searches for the shared mechanisms behind this phenomenon. Using genome comparisons and gene expression analysis, the lab hopes to elucidate the mechanisms that created biodiversity.
Yuasa Hideya, Professor
1 student voices
Yuasa Lab develops functional molecules using organic chemistry, aiming to control the functions of biomolecules with light. The lab creates molecules that combine light-responsive molecules with biomolecules such as sugars, lipids, nucleic acids, and peptides. Through original molecular design and elucidation of how light acts on molecules, the lab produces light-responsive molecules never seen before. The lab applies this technology to the development of cancer therapies that are minimally invasive with few side effects, and to the development of molecular probes.
Hiroyuki Nakamura, Professor
1 student voices
The Nakamura-Okada Lab pursues drug discovery research aimed at new cancer treatments, based on synthetic organic chemistry. It focuses on microenvironments in the body, such as the hypoxic environment of cancer cells and local nuclear reactions. It also aims for technological innovation in chemical biology, including the development of molecular modification methods that act selectively on protein surfaces. The lab works by designing and synthesizing molecules, evaluating them itself, and feeding the results back into the next design.
Hitoshi Nakatogawa, Professor
1 student voices
The Nakatogawa Lab studies the mechanism of autophagy, in which cells degrade their own components. In autophagy, a membrane appears inside the cell, encloses the material to be degraded, and carries it to the vacuole or lysosome, where it is broken down. Using budding yeast, the lab examines at the molecular level how this membrane is formed and what it encloses. Combining various methods, from microscopy observation to reconstitution in test tubes, the lab tackles these mysteries.
Shinji Masuda, Professor
1 student voices
The Masuda Lab studies how photosynthetic organisms adapt to changes in their environment. Almost all the energy that sustains life on Earth ultimately comes from sunlight, and photosynthesis underpins it. Research on photosynthesis therefore contributes to a wide range of fields involving living organisms, as well as to solving energy and environmental problems. Each student has their own unique theme and continues to publish cutting-edge results.
Nobuhiro Nishiyama, Professor
1 student voices
The Nishiyama-Miura Lab studies the development of drugs that act precisely as intended inside the body, built on precisely synthesized polymers. On the polymers, the lab builds in functions for carrying a drug, attaching to target cells, and changing shape in response to the environment inside cells. The lab aims to put into practical use cancer therapies that are highly effective with few side effects, as well as next-generation biopharmaceuticals such as antibodies and nucleic acids. The lab has facilities for everything from polymer synthesis to evaluation using cultured cells and laboratory animals.
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