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Genome Informatics Lab [Research Institute for Microbial Diseases]
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A lab that analyzes the genomes of pathogens and microbial communities using next-generation sequencers.

AboutAbout the lab
Deciphering pathogens and infectious diseases with next-generation sequencers
The Nakamura Lab (Infectious Disease Metagenomics) conducts research aimed at understanding infectious diseases through genome analysis and metagenomic analysis of pathogens using next-generation sequencers.
A metagenome is a concept that treats the genomes derived from a community of organisms living in an environment as a single aggregate.
The lab also studies human commensal microbes, especially the gut microbiota, and conducts structural biology research on how pathogens colonize the intestinal tract.
The lab belongs to the Bioinformatics Center of the Research Institute for Microbial Diseases.
Key terms
- Next-generation sequencer
- A device that can read vast amounts of genetic information in a short time. It only reads nucleic acid sequences, so separate methods are needed to analyze the data
- Metagenome
- A concept that treats the genomes derived from a community of organisms living in an environment as a single aggregate
- Gut microbiota
- The community of bacteria living in the intestine
ResearchResearch themes
The Infectious Disease Metagenomics lab aims to understand pathogens and infectious diseases through genome analysis and metagenomic analysis using next-generation sequencers. Specialist staff in microbiology, infectious disease science, and bioinformatics work together on the research.
*Illustrative imageNext-generation sequencers and data analysis
A next-generation sequencer is a device that only reads nucleic acid sequences, so the huge amount of data it produces requires analysis methods. Experts in microbiology, genomics, and bioinformatics collaborate, using a large-scale computer system to analyze big data.
*Illustrative imageGenome and metagenome analysis of pathogens
The lab identifies genes that act as virulence factors from pathogen genomes and works to clarify the molecular mechanisms by which infectious diseases arise. It is also working to establish methods for detecting and diagnosing pathogens through metagenomic analysis.
*Illustrative imageHuman commensal microbes and the gut microbiota
The lab performs metagenomic analysis of the gut microbiota in various diseases and in diarrheal illness to examine the relationships among humans, gut bacteria, and pathogens. It also studies how pathogenic microbes colonize the intestine using structural biology methods, with the goal of developing treatments that can replace antibiotics.
MembersFaculty
The members of the Nakamura Lab consist of faculty (including faculty with concurrent appointments), Project Assistant Professors, and project researchers.As of 2026
- ProfessorShota Nakamura
- Professor (Concurrent)Tetsuya Iida
- Professor (Concurrent)Takayuki Kato
- Lecturer (Concurrent)Daisuke Motooka
- Project Assistant ProfessorDaiya Oki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “Next Gen Sequencer (NIH BioArt 386)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Next-generation sequencers and data analysis: “Next generation sequencing slide” Bainscou / CC BY 3.0 (cropped)
- Genome and metagenome analysis of pathogens: “Single Cell Genome Sequencing (MDA)” Qianlim / Public domain (cropped)
- Human commensal microbes and the gut microbiota: “E. coli Bacteria ( )” NIAID / Public domain (cropped)
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