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Hospital Pharmacy Lab, Department of Clinical Pharmacology [Osaka University Hospital] (Semi-core Field)
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A hospital pharmacy lab that explores how to use drugs appropriately through both basic and clinical research.
AboutAbout the lab
Near-future medicine, created by Pharmacist-Scientists.
The Hospital Pharmacy lab is located within the Department of Pharmacy at Osaka University Hospital, and conducts research to ensure the efficacy and safety of drugs and to promote their appropriate use.
Based on pharmacokinetics, cell biology, and epidemiology, the lab carries out both clinical and basic research.
Its research ranges from establishing and putting personalized medicine into practice to drug repositioning.
The lab accepts graduate students (including working-professional graduate students) from the Graduate School of Medicine and the Graduate School of Pharmaceutical Sciences at Osaka University, and welcomes visits from pharmacists and students.
Key terms
- drug repositioning
- An approach that explores whether drugs already in use could be used for diseases or symptoms other than their original purpose.
- drug transporter
- A protein that takes drugs into cells or moves them out of cells.
- pharmacometrics
- A method that analyzes data on how drugs behave and act in the body using mathematical models, in order to identify the factors behind individual differences in efficacy and side effects.
- EGFR-TKI
- A molecularly targeted drug used for lung cancers with EGFR gene mutations.
ResearchResearch themes
The lab conducts research to ensure the efficacy and safety of pharmaceuticals and to use them appropriately. Based on pharmacokinetics, cell biology, and epidemiology, it approaches this through both clinical and basic research.
*Illustrative imageNew Ways to Prevent Side Effects of Anticancer Drugs
Pursuing questions from clinical practice from the standpoint of pharmacokinetics, the lab searches for drugs that prevent the side effects of anticancer drugs by exploiting drug-drug interactions mediated by drug transporters. It has found that co-administering a proton pump inhibitor reduces cisplatin-induced kidney injury.
*Illustrative imagePersonalized Dosing of Immunosuppressants
Using pharmacometrics, the lab applies population PK/PD models to identify factors that influence the efficacy and side effects of drugs. At Osaka University Hospital, one of the facilities able to perform transplants of all organs, this work focuses mainly on immunosuppressive therapy after organ transplantation.
*Illustrative imageBiomarkers of Treatment Resistance to Molecularly Targeted Drugs
EGFR-TKIs are highly effective against lung cancers with EGFR gene mutations, but resistance develops in almost all cases as treatment continues. The lab investigates factors involved in this resistance, such as the translation initiation factor eIF3c and miR-130a-3p contained in extracellular vesicles.
MembersFaculty
The members of the Hospital Pharmacy lab consist of supervising staff, graduate students, and undergraduate students from the Faculty of Pharmaceutical Sciences.As of 2025
- ProfessorMasahiro Okuda
- Associate ProfessorKenji Ikemura
- Associate ProfessorShinichiro Maeda
- Project Assistant ProfessorAkihiro Yamane
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Pills and medicines 01” BuhaM / CC BY-SA 4.0 (cropped)
- New Ways to Prevent Side Effects of Anticancer Drugs: “X-Ray diffraction structure of Cisplatin intra-strand GG adducts” PDB code 1AIO CRYSTAL STRUCTURE OF A DOUBLE-STRANDED DNA CONTAINING THE MAJOR ADDUCT OF THE ANTICANCER DRUG CISPLATIN Author(s): Takahara, P.M., Rosenzweig, A.C., Frederick, C.A., Lippard, S.J. PDB DOI: 10.2210/pdb1AIO/pdb / CC BY-SA 4.0 (cropped)
- Personalized Dosing of Immunosuppressants: “Immunosuppressive drugs modes of action” Maria Meneghini ,Oriol Bestard ,Josep Maria Grinyo / CC BY 4.0 (cropped)
- Biomarkers of Treatment Resistance to Molecularly Targeted Drugs: “Cancer de pulmon” Modificado de OpenStax College / CC BY-SA 3.0 (cropped)
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