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Cell Biology Lab [Institute of Scientific and Industrial Research] (Semi-core Field)
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A lab that targets drug efflux pumps to prevent infections caused by multidrug-resistant bacteria.
AboutAbout the lab
Preventing infections caused by multidrug-resistant bacteria before they occur.
Nishino Lab studies how to prevent infections caused by multidrug-resistant bacteria, which cannot be killed by antibiotics.
Using post-genomic approaches, the lab has comprehensively investigated the drug resistance factors latent in bacterial genomes.
The lab is developing inhibitors that target drug efflux pumps, which expel antibiotics and other compounds from inside the cell, and the factors that regulate them.
On the lab's website, it is introduced as the Biomolecular Regulation Science research division of the Institute of Scientific and Industrial Research, together with the Cell Biology division (Biological) of the Graduate School of Pharmaceutical Sciences.
Key terms
- multidrug-resistant bacteria
- Bacteria that can no longer be killed by antibiotics. They are frequently detected in clinical settings and in the environment.
- drug efflux pump
- A mechanism that expels antibiotics and other compounds from inside the cell. It is a cause of multidrug resistance.
ResearchResearch themes
Aiming to prevent infections caused by multidrug-resistant bacteria before they occur, the lab investigates drug resistance factors latent in bacterial genomes. It is developing inhibitors that target drug efflux pumps and their regulatory factors.
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MembersFaculty
- ProfessorKunihiko Nishino
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Antibiotic resistant bacteria” Microrao / CC BY-SA 4.0 (cropped)
- Drug Efflux Pumps and Their Regulation: “Antibiotic sensitivity and resistance” Dr Graham Beards / CC BY-SA 4.0 (cropped)
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