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Mandom Advanced Cosmetic Science Collaborative Research Lab
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A lab that studies how the skin and sweat glands work and applies the findings to cosmetics development.
AboutAbout the lab
Toward groundbreaking cosmetics developed with advanced medical technology
The Mandom Advanced Cosmetic Science Collaborative Research Lab uses human tissues, organs, and isolated cells to study the mechanisms of proteins and genes involved in the skin and in the organs and cells around it.
The lab aims to apply advanced medical technologies, such as regenerative medicine and immunotherapy, to cosmetics development.
It carries out its research with the cooperation of the Graduate School of Pharmaceutical Sciences, the Graduate School of Medicine, and other research institutions.
The lab is recruiting graduate students who are interested in research using state-of-the-art equipment and in research that leads to cosmetics.
Key terms
- Ion channel
- A protein pathway in the cell membrane that lets ions pass through. Some ion channels relay changes in the outside environment to the cell
- Sweat gland myoepithelial cells
- One type of cell that makes up the sweat gland. This lab has established immortalized cells of this type
- Screening
- The process of selecting drugs or active ingredients that meet a given purpose from among many candidates
NewsLab news
Mandom Corporation, together with Project Professor Makoto Tominaga, received the 51st Inoue Harushige Prize
A doctoral student received the Outstanding Student Presentation Award at the 3rd Annual Scientific Meeting of the Society of Cosmetic Chemists of Japan
A master's student received the Outstanding Student Presentation Award at the 1st Annual Scientific Meeting of the Society of Cosmetic Chemists of Japan
ResearchResearch themes
The lab aims to understand at the molecular level how the skin stays healthy and to apply that understanding to cosmetics development. Using human-derived cells, artificial skin, and similar materials, it studies safety evaluation, skin immunity, sweat glands and sebaceous glands, and the development of next-generation cosmetics.
*Illustrative imageSafety evaluation without animals
Many cosmetic safety tests use laboratory animals. The lab aims for evaluation that uses no animals at all, and uses human-derived samples such as cells and artificial skin to study how skin inflammation and irritation occur.
*Illustrative imageMechanisms of skin immunity
The skin protects the body from changes in the external environment and from pathogens, and its barrier function weakens in conditions such as atopic dermatitis. The lab studies the mechanisms of skin immunity, focusing on organelles and ion channels, and links the findings to cosmetics that support healthy skin.
*Illustrative imageFunctions of sweat glands and sebaceous glands
Sweat gland dysfunction is said to cause conditions such as hyperhidrosis and heat illness, and the lab studies how human sweat glands function and are regulated. It has established immortalized sweat gland myoepithelial cells for use in drug screening, and it also focuses on sebaceous glands, aiming for new drugs and cosmetics that use ingredients able to control sebum.
*Illustrative imageDevelopment of next-generation cosmetics
The lab is developing next-generation cosmetics that contain new active ingredients, based on a molecular-level understanding of how the skin stays healthy. With the cooperation of experts in Japan and abroad, it has established new evaluation methods that apply molecular biology and uses them to screen active ingredients.
MembersFaculty
The members of the Mandom Advanced Cosmetic Science Collaborative Research Lab are faculty, visiting faculty, joint researchers from companies and other organizations, visiting researchers, JSPS postdoctoral fellows, doctoral and master's students, research students, and administrative staff.As of 2026
- Visiting ProfessorFumitaka Fujita
- Visiting ProfessorAtsushi Tanemura
- Visiting Associate ProfessorTakeshi Hara
- Visiting Associate ProfessorMotoki Nakamura
- Project Associate ProfessorHiroko Kato
- Project Associate ProfessorManami Toriyama
- Assistant Professor (Concurrent)Naoya Otani
- Professor (Concurrent)Tatsuya Saito
- Professor (Concurrent)Tatsuki Kubo
- Professor (Concurrent)Manabu Fujimoto
- Lecturer (Concurrent Appointment)Yukinobu Nakagawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Sweat gland histology 2014” Athikhun.suw / CC BY-SA 4.0 (cropped)
- Safety evaluation without animals: “Cell culture lab” Ybustanji / CC BY-SA 4.0 (cropped)
- Mechanisms of skin immunity: “Epidermis histology 2014” Athikhun.suw / CC BY-SA 4.0 (cropped)
- Functions of sweat glands and sebaceous glands: “Gray940 - sweat gland” Henry Gray / Public domain (cropped)
- Development of next-generation cosmetics: “Optical caustic Cosmetic oil bottle in the sun mj” Mariojan photo / CC BY 4.0 (cropped)
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