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Compound Library Screening Center, Drug Target Discovery Unit, Muscle Stem Cell Drug Discovery Project Lab
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A lab that explores treatments for muscle diseases through the mechanisms of muscle stem cells.
AboutAbout the lab
Uncovering the power of skeletal muscle at the molecular level.
The Muscle Stem Cell Drug Discovery Project studies the regenerative and hypertrophic capacity of skeletal muscle at the molecular level.
The lab investigates how muscle satellite cells, the stem cells of skeletal muscle, are maintained and how they function in muscle regeneration and hypertrophy.
Aiming for discoveries that lay the foundation for developing treatments for muscle diseases, the lab also has muscular dystrophy, sarcopenia, and cancer cachexia in view.
The lab's website is operated under the name of the Field of Regeneration and Adaptation.
Key terms
- Muscle satellite cell
- A stem cell of skeletal muscle. It is maintained in a quiescent state and is involved in muscle regeneration and hypertrophy
- Muscular dystrophy
- A type of hereditary muscle disease. Basic research toward developing treatments is under way
- Sarcopenia
- A condition in which muscle atrophy, the wasting of muscle, is a problem
NewsLab news
A doctoral student received an Excellence Award in the Student Award at the Annual Meeting of the Japanese Society of Myology
An invited review summarizing research on regenerative treatment for muscular dystrophy was published in Cell Regeneration
A collaborative study with Kyoto Prefectural University was published in PNAS
A student received the Kusumoto Prize and the Osaka University Outstanding Research Award for Female Graduate Students
An undergraduate student received an Excellence Award at the midterm presentation of the long-term project practicum
ResearchResearch themes
The lab studies the mechanisms of skeletal muscle regeneration and hypertrophy at the molecular level, centering on muscle satellite cells, the stem cells of skeletal muscle. Based on its findings, the lab aims to build a foundation that leads to treatments for hereditary muscle diseases, for sarcopenia, in which muscle atrophy is a problem, and for cancer cachexia.
*Illustrative imageHow Muscle Stem Cells Stay Quiescent
The lab investigates how muscle satellite cells, the stem cells of skeletal muscle, are maintained in a quiescent state. At the molecular level, it focuses on Hey1/HeyL, which are effectors of Notch signaling, and on the calcitonin receptor.
*Illustrative imageHow Muscles Grow
The lab takes its own approach to classic questions: why skeletal muscle grows with resistance training, how muscle hypertrophy relates to muscle damage, and whether muscle satellite cells are involved.
*Illustrative imageHow Muscles Regenerate
Muscle regeneration is completed by multiple types of cells acting in an orderly way in time and space. The lab focuses on the interactions among muscle satellite cells, blood-lineage cells, stromal cells, and the basement membrane, aiming to elucidate the mechanisms of regeneration.
*Illustrative imageDeveloping Treatments for Muscle Diseases
Based on its original research findings, the lab conducts basic research toward developing treatments for hereditary muscle diseases. It is currently also pursuing research with an interest in sarcopenia and cancer cachexia, in which muscle atrophy is a problem.
MembersFaculty
The members listed on the lab's website consist of faculty members, researchers, doctoral, master's, and undergraduate students, and secretaries.As of 2026
- ProfessorSoichiro Fukada
- LecturerKentaro Jinguji
- Assistant ProfessorTakuaki Hase
- Assistant ProfessorJun Kubo
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “High-throughput screening” Tiia Monto / CC BY-SA 3.0 (cropped)
- How Muscle Stem Cells Stay Quiescent: “Multinuclear muscle fiber cells and some associated mononuclear cells” MethylC5 / CC BY-SA 4.0 (cropped)
- How Muscles Grow: “Skeletal muscle 400x” Alexander G. Cheroske / CC BY-SA 4.0 (cropped)
- How Muscles Regenerate: “Muscle Tissue Capilary in Skeletal Muscle ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Developing Treatments for Muscle Diseases: “1025 Atrophy” OpenStax / CC BY 4.0 (cropped)
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