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Transformative Human Specimen Analysis Lab
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A lab that advances infectious disease specimen analysis through collaboration among hospitals while also training the next generation of researchers.
AboutAbout the lab
Testing, training, innovation.
The Endowed Department of Transformative Human Specimen Analysis aims to train people who can build new specimen analysis systems, as well as the next generation of researchers who aspire to a career in medicine.
The lab is developing a collaborative research framework that links university hospitals across western Japan, and building a shared research foundation for infectious disease studies among hospitals in Osaka.
It is also working to build a diagnostic framework using metagenomic next-generation sequencing for cases in which the causative microorganism is hard to identify.
The lab also runs an educational program for high school students interested in infectious diseases and microorganisms.
Key terms
- Metagenomic next-generation sequencing
- A method that reads the genetic information of all the microorganisms in a specimen at once to look for the cause of an infection
- Culture-negative
- A condition in which the causative microorganism was not found even after the specimen was cultured
- Bacteremia
- A condition in which bacteria have entered the bloodstream
- DWH (data warehouse)
- A repository that collects clinical data and organizes it so that it can be used for research
ResearchResearch themes
The lab works with university hospitals in western Japan and hospitals in Osaka to build a foundation for research that analyzes specimens from infectious disease patients. It also aims to train people who can build new specimen analysis systems, as well as the next generation of researchers.
*Illustrative imageCollaborative research with university hospitals in western Japan
The lab has built MIRAI-ID, a multicenter research alliance linking university hospitals across western Japan. Its projects include genetic analysis of group B Streptococcus (GBS) isolated from blood cultures of adult patients and a multicenter retrospective study of Citrobacter koseri bacteremia.
*Illustrative imageInfectious disease research infrastructure in Osaka hospitals
Using a common data warehouse (DWH) shared by hospitals in Osaka, including Osaka University Hospital and Osaka General Medical Center, the lab is establishing a foundation for multicenter infectious disease research. It is planning studies that evaluate the performance of disease-name-based diagnosis for diseases covered by the Infectious Diseases Control Act, and a study of disseminated cryptococcosis in patients without HIV infection.
*Illustrative imageMetagenomic next-generation sequencing diagnostics
The lab aims to identify the causative microorganism in culture-negative cases and cases that are difficult to diagnose. Centered on Osaka University Hospital, it is building a diagnostic platform based on metagenomic next-generation sequencing (mNGS).
*Illustrative imageEducational program for high school students
To increase the number of high school students interested in infectious diseases and microorganisms, the lab runs an educational program called the BUGS workshop. It is committed to training the next generation of researchers who aspire to a career in medicine.
MembersFaculty
- Associate Professor, Endowed ChairRyuichi Sada
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “DNA gel- southern blotting” John Crawford (Photographer) / Public domain (cropped)
- Collaborative research with university hospitals in western Japan: “Blood culture gram stain of Gram positive cocci” Spicy / CC BY-SA 4.0 (cropped)
- Infectious disease research infrastructure in Osaka hospitals: “Cryptococcus in India Ink” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Metagenomic next-generation sequencing diagnostics: “Illumina MiSeq” Konrad Förstner / CC BY 2.0 (cropped)
- Educational program for high school students: “Sagada National High School Basic Wikipedia Editing Workshop” nano banna pro / CC BY 4.0 (cropped)
- Related lab (Cell Recognition Mechanisms Lab): “Fluorescence Microscopy of Mycobacterium tuberculosis Following Auramine O Staining” Siduduziwe Nxumalo / CC BY-SA 4.0 (cropped)
- Related lab (Oncology Lab): “Vacuoles in cancer cells with non-invasive imaging” Annaleida / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Oncology Lab): “Breast cancer cells (2)” Dr. Cecil Fox (Photographer) / Public domain (cropped)
- Related lab (Circulatory Microimaging Medicine Lab): “1982 Prototype of a confocal Laser Scanning Microscope (LSM) ( )” ZEISS Microscopy from Germany / CC BY-SA 2.0 (cropped)
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