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Protein Physical Biology Lab
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A lab that measures heat production with an optical microscope and understands it by stimulating it with heat.

AboutAbout the lab
Thermal biology across scales.
The Protein Physical Biology Lab studies phenomena related to heat production in living organisms, aiming to understand them at the spatial scale of the cell.
The lab develops methods for local heat stimulation and for measuring temperature with an optical microscope.
It applies these methods to experimental systems at various spatial scales, from biomolecules to whole organisms.
Together with collaborators in Japan and abroad, the lab pursues both curiosity-driven themes in search of fundamental truths and disease-related themes.
Key terms
- Heat production
- The mechanism by which living organisms release heat. It is also what allows humans to maintain their body temperature
- Optical microscope
- A microscope that uses light to magnify small objects. This lab also uses it in its temperature-measurement technology
- Spatial scale
- The level of size of the object being studied. Here it refers to the range from biomolecules to cells and whole organisms
NewsLab news
A doctoral student's paper was selected for the cover of ACS Sustainable Chem. Eng.
A paper by Associate Professor Suzuki and colleagues was published in ACS Sustainable Chemistry & Engineering
A paper by Associate Professor Suzuki and colleagues was published in Journal of Smooth Muscle Research
A paper by Associate Professor Suzuki and colleagues was published in Biotechnology and Bioengineering
A doctoral student received a best poster presentation award at ISNM2024
ResearchResearch themes
The lab aims to understand phenomena related to heat production at the spatial scale of the cell, and develops methods for local heat stimulation and for measuring temperature with an optical microscope. It applies these methods to biological experiments at various spatial scales, from biomolecules to whole organisms.
View More ↗MembersFaculty
The members of the Protein Physical Biology Lab consist of faculty, a Project Professor, doctoral and master's students, interns, and a secretary.As of 2026
- Independent Associate ProfessorMadoka Suzuki
- Assistant ProfessorChongxia Zhong
- Project ProfessorHiroyuki Iwamoto
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Fungi seen with fluorescence microscope” Juan Carlos Fonseca Mata / CC BY 4.0 (cropped)
- Local heat stimulation and temperature measurement: “Binocular compound microscope, Carl Zeiss Jena, )” Chad Anderson, staff photographer for SFO Museum / CC BY-SA 2.0 (cropped)
- Related lab (Cell Function Design Lab): “Organoid (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Single-Molecule Biology Lab): “Fluorescence microscope” Sarathkumaran Ranganathan / CC BY-SA 4.0 (cropped)
- Related lab (Parasitology Lab): “Plasmodium falciparum gametocyte” Microrao / CC BY-SA 4.0 (cropped)
- Related lab (Biological Regulation Lab): “Fluorescence.microscope1” Bioguy10 / CC0 (cropped)
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