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Molecular Biomeasurement Lab
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A lab that explores life phenomena such as cellular forces and aging through physics and measurement.
AboutAbout the lab
Finding Mechanics Within Life
The Molecular Biomeasurement Lab combines measurement; mathematical science, physics, statistics, and informatics; and molecular biology and genetic engineering to understand hierarchical and complex life phenomena.
The lab seeks to understand life phenomena such as cell shape, force, movement, and aging on the basis of physics, including mechanics, thermodynamics, and statistical mechanics.
It also aims to open up a new field of biophysics and to achieve medical applications such as the regulation of aging.
On the lab's website, it is introduced under the name "Deguchi Lab."
Key terms
- Mechanosensing
- The mechanism by which cells sense mechanical information from their surroundings
- Soft matter physics
- A branch of physics that deals with collective phenomena in which many living entities gather, such as the migration of cell populations and the swimming of microorganisms
- Active matter physics
- A branch of physics that deals with how many individuals influence one another to produce ordered motion
NewsLab news
A doctoral student won a Poster Award at the international conference SMBT2026
Associate Professor Matsunaga received the Young Scientists' Award in the FY2026 Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology
A doctoral student received the JSPS Ikushi Prize
Professor Deguchi received the FY2025 Osaka University Award (Education Contribution category)
Published an article explaining a paper on cell measurement that combines the FRAP method with spatial statistics
ResearchResearch themes
The lab takes an interdisciplinary approach that combines measurement; mathematical science, physics, statistics, and informatics; and molecular biology and genetic engineering to understand hierarchical and complex life phenomena. It aims to open up a new field of biophysics and to achieve medical applications such as the regulation of aging.
*Illustrative imageA physical understanding of life phenomena
The lab aims to understand life phenomena such as cell shape, force, movement, and aging on the basis of physics, including mechanics, thermodynamics, and statistical mechanics. It combines experiments, mathematical models, and simulations.
*Illustrative imageHow cells sense their environment
The mechanism by which cells obtain mechanical information is called mechanosensing. The lab is clarifying which molecules act inside cells and how they convert force information into gene expression and cell fate.
*Illustrative imageNew technologies for measuring life phenomena
By combining new experimental devices, image analysis, and AI and machine learning, the lab develops technologies that measure cell states and forces with high accuracy. Examples include a simple method for measuring the forces generated by cells and an AI that estimates mechanical states from cell images.
*Illustrative imageCollective motion of cells and organisms
The lab studies the migration of cell populations, the swimming of microorganisms, the flocking of fish and birds, and the coordinated motion of artificial micro-robots from the perspectives of soft matter physics and active matter physics. It combines fluid dynamics, mechanics of materials, and mathematical models.
MembersFaculty
The lab's members consist of faculty, a Project Professor, visiting researchers, JSPS postdoctoral fellows, doctoral, master's, and undergraduate students, administrative assistants, and technical assistants.As of 2026
- ProfessorShinji Deguchi
- Associate ProfessorDaiki Matsunaga
- Assistant ProfessorShuichiro Fukushima
- Assistant ProfessorTakumi Saito
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Light Optical Microscope” Jeremyida002 / CC BY-SA 4.0 (cropped)
- A physical understanding of life phenomena: “Biophysics Lab ( )” The U.S. Food and Drug Administration / Public domain (cropped)
- How cells sense their environment: “SK8-18-2 human derived cells, fluorescence microscopy ( )” ZEISS Microscopy from Germany / CC BY 2.0 (cropped)
- New technologies for measuring life phenomena: “Transmission electron microscope (3)” Gannu03 / CC BY-SA 4.0 (cropped)
- Collective motion of cells and organisms: “Flock of munia” Abhijith Photography / CC BY-SA 4.0 (cropped)
- Related lab (Thermal Engineering Lab): “Boundary-Layer-Transition” Herbert.Oertel / www.prof.oertel.de / CC BY-SA 3.0 (cropped)
- Related lab (Fluid Mechanics Lab): “Magnetic turbulence” Giannandrea Inchingolo / CC BY-SA 4.0 (cropped)
- Related lab (Materials Physics Lab): “Transmission electron microscope (Morgagni 268D) pl” Pleple2000 / CC BY-SA 3.0 (cropped)
- Related lab (Solid Mechanics Lab): “Origami ball” Angie from Sawara, Chiba-ken, Japan / CC BY 2.0 (cropped)
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