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Human Genome Diversity Lab
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The lab explores the evolutionary history that humankind has followed through differences in the human genome.
AboutAbout the lab
Exploring human evolution through genomic diversity
The Human Genome Diversity Lab studies the evolutionary history of humans through individual and population differences in the human genome (the complete set of genetic information).
The genomes of modern humans retain traces of the natural selection, population splits, admixture, and migrations that their ancestors experienced.
The lab combines fieldwork, experiments to examine genomic diversity, statistical and mathematical analysis, and computer simulation.
It also investigates how genetic differences relate to differences in individual traits such as body build.
Key terms
- Genome
- The complete set of genetic information of an organism. In humans, it consists of a sequence of about 3 billion bases.
- Natural selection
- The process by which genetic differences that affect survival or reproductive success spread through a population over generations.
- HLA genes
- Genes that code for proteins that present fragments of pathogens to immune cells. Their types vary greatly from person to person.
- Polymorphism
- A difference between individuals in the base sequence at the same position in a gene.
ResearchResearch themes
The lab aims to decipher the events that ancestors experienced from human genomic diversity and to clarify the evolutionary history of humans. It also studies how genetic diversity affects the diversity of traits such as body build.
*Illustrative imageNatural Selection Left in the Genome
The lab uses sequence and polymorphism analysis together with simulation to find genes that have undergone "positive natural selection," in which advantageous mutations spread through a population. It also studies HLA genes, whose polymorphisms have been inherited across species.
*Illustrative imagePopulation Origins, Migration, and Admixture
Using genome-wide data, the lab investigates how Japanese populations formed, including admixture between the Jomon people and later migrants from the continent. It also studies the routes by which people who settled in Oceania spread, as well as admixture between populations.
*Illustrative imageInfectious Diseases and Human Genetic Adaptation
Among patients with malaria and dengue fever in Thailand, the lab searches for gene polymorphisms associated with susceptibility to severe disease and analyzes their evolution. It also studies the interplay between human genes and pathogen genes.
*Illustrative imageBody Build and Metabolism in Oceanic Peoples
A constitution that can store energy from little food was advantageous for ocean voyaging, but is now thought to contribute to obesity and related conditions. The lab searches for polymorphisms related to body build and lipid metabolism in people of Oceania.
MembersFaculty
The members of the Human Genome Diversity Lab consist of faculty members, visiting researchers, and graduate students.As of 2022
- ProfessorJun OhashiPublications ↗
- Project Assistant ProfessorNaka IzumiPublications ↗
- Project Assistant ProfessorMariko IsshikiPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Japan (MODIS )” Jeff Schmaltz, MODIS Land Rapid Response Team, NASA GSFC / Public domain (cropped)
- Natural Selection Left in the Genome: “HLA-A1” Pdeitiker / Public domain (cropped)
- Population Origins, Migration, and Admixture: “Polynesian double-hulled voyaging canoes sheltering in Kealakekua Bay, Hawaii - panoramio” Peter Gill / UK / CC BY 3.0 (cropped)
- Infectious Diseases and Human Genetic Adaptation: “Anopheles gambiae mosquito feeding 1354.p lores” Content Providers(s): CDC/James Gathany Photo Credit: James Gathany / Public domain (cropped)
- Body Build and Metabolism in Oceanic Peoples: “Tonga - Nuku and Fukave islands, Tongatapu group” Stefan Heinrich (Msdstefan at de.wikipedia) / CC BY-SA 3.0 (cropped)
- Related lab (ゲノム人類学研究室): “Jomon period human skull with forked tooth ablation, excavated from the Ikawazu Shell Mound” Saigen Jiro / Public domain (cropped)
- Related lab (遺伝学研究室(大谷研)): “Arabidopsis thaliana kz07” Krzysztof Ziarnek, Kenraiz / CC BY-SA 4.0 (cropped)
- Related lab (人類進化生体力学研究室(荻原研究室)): “Biomechanics lab with force plate” Apfriesen / CC BY-SA 4.0 (cropped)
- Related lab (植物進化生態学研究室): “P1000491 Petunia axillaris (Solanaceae) Flower” Magnus Manske / CC BY-SA 3.0 (cropped)
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