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Nishiyama Genome Integrity and Control Lab
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A lab that explores how genomes are inherited through the structure and movement of chromosomes.
AboutAbout the lab
How does a cell package and divide two meters of DNA?
The Genome Integrity and Control Division (Nishiyama Lab) studies how the genome is passed on to cells of the next generation in the form of chromosomes.
The lab examines the structural changes chromosomes undergo, from genome replication through condensation into mitotic chromosomes to equal segregation into two daughter cells.
Higher-order chromosome structure is also important for regulating gene expression, and defects in it are known to cause hereditary diseases.
Key terms
- Chromatin
- A structure in which DNA is wound around proteins, forming the basis of chromosomes
- Mitotic chromosome
- A chromosome formed when DNA is tightly condensed as a cell divides
- Daughter cell
- One of the two new cells produced when a cell divides
ResearchResearch themes
The lab studies the series of chromosome structural changes from genome replication through condensation and segregation, and their molecular basis.
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MembersFaculty
The members of the Genome Integrity and Control Division include faculty, JSPS Research Fellows, graduate students, undergraduates, and support staff.As of 2026
- ProfessorTomoko Nishiyama
- Assistant ProfessorYoshimi Kinoshita
- Assistant ProfessorMakoto Yoshida (Kozai)
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mitosis vs. Meiosis” Edn0987 / CC BY 4.0 (cropped)
- Chromosome Structural Changes and Segregation: “Cell division - Mitosis 7 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (Kyoto University Institute for Chemical Research, Biomolecular Information Lab): “Arabidopsis halleri flower (01)” Andrea Moro / CC BY-SA 4.0 (cropped)
- Related lab (Theoretical Biophysics Lab): “Schematic of a single-tethered DNA curtain” Soyeong An, Youngseo Kim, and Ja Yil Lee / CC BY 4.0 (cropped)
- Related lab (Plant Systematics and Taxonomy Lab): “Ranunculus lingua herbarium specimen by Joseph Witry” Musée national d'histoire naturelle Luxembourg / CC BY 4.0 (cropped)
- Related lab (Kyoto University Institute for the Evolution of Human Behavior (Eishi Hirasaki) Lab): “Coquerel's sifaka lemur (Propithecus coquereli) terrestrial locomotion” Charles J. Sharp / CC BY-SA 3.0 (cropped)
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