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Developmental System Control Lab
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The lab creates three-dimensional tissues from stem cells in vitro.
AboutAbout the lab
Uncovering how organs form, in vitro
The Developmental System Control Lab aims to understand the principles by which organs such as the brain and heart are built through cell proliferation, differentiation, and migration, and to recreate functional organ formation in vitro.
The lab develops technologies for recreating organ formation using pluripotent stem cells (ES cells/iPS cells), analyzes the formation process, and investigates the mechanisms by which many cells cooperate to build functional organs.
Key terms
- Organoid
- A small, three-dimensional organ-like tissue made in vitro from stem cells or similar cells
- Pluripotent stem cell
- A cell that can differentiate into every type of cell in the body. ES cells and iPS cells are examples
- Planar cell polarity
- The property of cells having a uniform orientation along the plane of a tissue. It can also be seen in the flow of hair and body hair
ResearchResearch themes
By recreating organ formation in vitro with pluripotent stem cells and analyzing the formation process, the lab works to elucidate the mechanisms by which many cells cooperate to build functional organs.
*Illustrative imageBuilding functional tissues from stem cells
Taking advantage of the ability of multicellular aggregates to acquire patterns and three-dimensional shapes through self-organization, the lab has developed technologies to form layered cerebral tissue and retinal tissue from ES/iPS cells, and also conducts basic research toward applications in regenerative medicine and drug discovery.
*Illustrative imagePolymer materials that shape organoids
The lab develops polymer materials for controlling the three-dimensional shape and pattern formation of organs more precisely. Using photocurable hydrogels, it has developed technologies such as controlling the three-dimensional shape of retinal organoids without damaging the cells.
*Illustrative imageCharacterizing human ES cells
Primate (monkey and human) ES cells have traits quite different from those of mouse ES cells, which come from rodents. Using new genetic modification technologies and cell manipulation methods, the lab investigates the molecular basis and significance of the properties characteristic of primate ES cells.
*Illustrative imageCreating and understanding planar cell polarity
The lab visualizes cell-cell and protein-protein interactions in African clawed frog (Xenopus) embryos to study the principles by which planar cell polarity forms. It has also developed an experimental system that artificially orients cultured cells, which have no inherent direction, on a culture dish.
MembersFaculty
- ProfessorMototsugu Eiraku
- Associate ProfessorMasatoshi Ogushi
- Assistant ProfessorYusuke Mii
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Retina Organoid (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Building functional tissues from stem cells: “Organoid during development ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Polymer materials that shape organoids: “Cell on 2D Monolayer vs. 3D Hydrogel with RGD” Lisa Zlanino / CC BY-SA 4.0 (cropped)
- Characterizing human ES cells: “Humanstemcell” Ryddragyn at English Wikipedia / Public domain (cropped)
- Creating and understanding planar cell polarity: “Xenopus laevis embyro” Emily / CC BY 4.0 (cropped)
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