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Nano Bioengineering Lab
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The lab uses nanoscale flows to measure both the properties and the genes of individual cells.
AboutAbout the lab
Applying nanoscale mechanics to bioengineering.
The Nano Bioengineering Lab develops new bioengineering that makes use of physical phenomena at the micro and nano scales, with the aim of understanding biological phenomena that remain unexplained.
The lab seeks to understand, across scales from a single cell to a whole organism, how groups of cells give rise to complex biological phenomena.
The lab works as an interdisciplinary team of researchers with diverse backgrounds, including engineering, science, and medicine.
Established in April 2023 at the Institute for Life and Medical Sciences, the lab is a cooperating laboratory of the Department of Micro Engineering in the Graduate School of Engineering.
Key terms
- Omics
- A research approach that comprehensively examines the genes, proteins, and other molecules in cells all at once
- Single-cell RNA sequencing
- A technology that reads out which genes are active, and to what extent, in each individual cell
- Electroporation
- A method of applying electrical pulses to cells to open tiny pores in their membranes so that substances can be introduced from outside
ResearchResearch themes
The lab aims to understand, across scales from single cells to whole organisms, how cell populations give rise to complex biological phenomena. To do so, it develops new omics measurement methods that make use of micro- and nanofluidics and electrokinetics.
*Illustrative imageMeasuring cell stiffness and gene activity at the same time
By combining nanoelectroporation with single-cell RNA sequencing, the lab has developed a method to measure the surface tension and gene activity of individual cells simultaneously at a large scale.
*Illustrative imageLinking microscope images with gene information
Even cells with the same genes respond differently to drugs. The lab is developing a method that links microscope images of cells with single-cell gene expression data using combinations of fluorescent colors and DNA barcodes, in order to uncover the mechanisms behind this variability.
MembersFaculty
- ProfessorHirofumi Shintaku
- Program-Specific Associate ProfessorAkifumi Shiomi
- Assistant ProfessorTaikopaul Kaneko
- Assistant ProfessorMisa Minegishi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Flow Focusing Device” Kimbalm / CC BY-SA 4.0 (cropped)
- Measuring cell stiffness and gene activity at the same time: “Cell in a microchannel” Lauraswikiacount / CC BY-SA 4.0 (cropped)
- Linking microscope images with gene information: “Laser TIRF )” ZEISS Microscopy from Germany / CC BY-SA 2.0 (cropped)
- Related lab (Microbiosystem Lab): “Lab on a Chip ( )” National Institute of Standards and Technology / Public domain (cropped)
- Related lab (Biomechanics Lab): “Expérimentation sur l'influence des courbures rachidiennes hautes sur la biomécanique du membre supérieur, en lien avec le risque de troubles musculosquelettiques” Sophie Jeannin / CC BY-SA 4.0 (cropped)
- Related lab (Solid Mechanics Lab): “Transmission electron microscope (Morgagni 268D) 2pl” Pleple2000 / CC BY-SA 3.0 (cropped)
- Related lab (Quantum Beam Science Lab): “Ion Beam - GPN” NASA/GRC / Public domain (cropped)
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