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Cell Biochemistry Lab
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A lab that explores how skin and disease work through enzymes that link proteins together.
AboutAbout the lab
Exploring how skin and disease work, starting from enzymes that link proteins together.
The Cell Biochemistry Lab studies the physiological and pathological roles of transglutaminase, an enzyme that cross-links proteins to bond them together.
Using cultured cells and animal models, the lab investigates how the epidermis of the skin forms, fibrosis in which tissue becomes hardened, and blood coagulation.
The lab also establishes mice and medaka as disease model organisms and analyzes them.
The lab accepts fourth-year students from the Department of Applied Biosciences in the School of Agricultural Sciences to carry out their graduation research.
Key terms
- Transglutaminase
- An enzyme that cross-links proteins to bond them together. It acts in processes such as skin formation and blood coagulation.
- Fibrosis
- The hardening of tissue. It occurs in conditions such as liver cirrhosis and nephritis.
- Genome editing
- A cutting-edge gene manipulation technology that introduces mutations into specific genes.
NewsLab news
A master's student received the Young Investigator Award at the Hypoxia Research Meeting
Professor Kiyotaka received the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA) Meritorious Achievement Award
A master's student received the Excellent Presentation Award in the student poster session at the Amano Enzyme Research Grant Report Meeting
A master's student received the Chubu Branch Encouragement Award at the JSBBA Chubu Branch regular meeting
A master's student received a Poster Award at an international conference on transglutaminase
ResearchResearch themes
The lab aims to clarify the physiological and pathological roles that the reaction of cross-linking and bonding proteins plays in the body. It investigates biological phenomena such as skin formation, fibrosis, and blood coagulation using techniques from molecular cell biology and protein biochemistry.
*Illustrative imageHow the Epidermis of the Skin Forms
At the surface of the skin, transglutaminase cross-links proteins to build a protective barrier. Using epidermal cells grown in three-dimensional culture, the lab studies how exposure to air promotes differentiation, focusing on the hypoxic response.
*Illustrative imageTissue Fibrosis and Disease
Focusing on tissue fibrosis associated with liver cirrhosis, kidney failure, and pulmonary fibrosis, the lab studies how these diseases develop using disease model animals and cultured cells. It aims to clarify the disease states caused by the formation of abnormal cross-links and to develop methods for prevention and treatment.
*Illustrative imageBlood Coagulation and Genes Studied in Medaka
Using genome editing, the lab creates medaka that lack genes involved in blood coagulation and studies them as models of coagulation disorders. It has also developed medaka in which the enzyme Cre can be activated only in the liver or the epidermis.
MembersFaculty
The members of the Cell Biochemistry Lab are faculty, technical staff, technical assistants, doctoral, master's, and undergraduate students, and external researchers.As of 2026
- ProfessorKiyotaka Kiyotaka
- Assistant ProfessorHideki Tatsukawa
- Assistant ProfessorTokuji Tsuji
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Alphafold structure model of pseudonajatoxin b” UniProt database / CC BY 4.0 (cropped)
- How the Epidermis of the Skin Forms: “HaCaT Cells Phase Contrast” Accuratelibrarian / CC BY-SA 4.0 (cropped)
- Tissue Fibrosis and Disease: “Biochemistry laboratory MPI-CBG-panorama” Masur / CC BY-SA 3.0 (cropped)
- Blood Coagulation and Genes Studied in Medaka: “Oryzias latipes(Hamamatsu,Shizuoka,Japan,2007)-2” Seotaro / CC BY-SA 3.0 (cropped)
- Related lab (Molecular Cell Regulation Lab): “Calmodulin 1CLL” 作者不詳 / Public domain (cropped)
- Related lab (Applied Microbiology Lab): “Geweihförmige Holzkeule - Staghorn fungus - Xylaria hypoxylon - 01” Norbert Nagel / CC BY-SA 3.0 (cropped)
- Related lab (Biochemistry Lab): “Arabidopsis thaliana kz08” Krzysztof Ziarnek, Kenraiz / CC BY-SA 4.0 (cropped)
- Related lab (Genome Information Function Lab): “Synechococcus cyanobacteria-cultures” Masur / Public domain (cropped)
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