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Natural Products Chemistry Lab
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The lab works on the total synthesis of complex natural products and the development of new reactions.
AboutAbout the lab
Powerful synthesis of complex natural products.
The Natural Products Chemistry Lab works on developing new reactions and establishing efficient synthetic methods through the synthesis of structurally complex natural organic compounds.
Its goal is to realize "powerful synthesis", which can supply as much of a useful organic compound as humanity needs.
Research themes are the total synthesis of natural products, the development of new synthetic methodologies, and the design and synthesis of functional compounds aimed at drug discovery.
On the lab's website, it is introduced under the name "Natural Products Chemistry Division".
Key terms
- Total synthesis
- Synthesis in which a complex natural product is artificially made from scratch, from simple starting materials, through a series of chemical reactions.
- Photoaffinity probe
- A compound that becomes fixed to its binding partner protein when irradiated with light, serving as a marker for finding that partner.
- Structure–activity relationship
- The relationship describing how the strength of a compound's effect on living organisms changes when its structure is changed.
NewsLab news
A master's student won the Best Presentation Award at the Joint Academic Meeting 2026 of the Tokai Block of the Japanese Society of Hospital Pharmacists and the Tokai Branch of the Pharmaceutical Society of Japan
A doctoral student won the Nagoya University Academic Encouragement Award for FY2026
A doctoral student won the Excellent Presentation Award at the 24th Symposium on Organic Chemistry for the Next Generation
A master's student won the Student Outstanding Presentation Award at the 146th Annual Meeting of the Pharmaceutical Society of Japan
A doctoral student won the GTR Research Award for FY2025
ResearchResearch themes
The lab works on the synthesis of structurally complex compounds, especially natural organic compounds, and aims to establish efficient synthetic methods through the development of new reactions and original synthetic design. Its goal is to realize "powerful synthesis", which can supply as much of a useful organic compound as humanity needs.
*Illustrative imageTotal synthesis of natural products
Through research on the synthesis of structurally complex natural products, the lab hopes to raise organic synthetic chemistry to a higher level. Developing new ways to build complex structures leads directly to the production of useful compounds.
*Illustrative imageDevelopment of new synthetic methodologies
The lab has developed highly versatile methodologies, such as amine synthesis using the nitrobenzenesulfonyl group and indole synthesis, and has applied them to the synthesis of natural products.
*Illustrative imageDesign and synthesis of compounds for drug discovery
The lab designs and synthesizes photoaffinity probes and affinity resins from natural products, and, together with collaborators, aims to analyze the function and structure of proteins that are drug discovery targets. It also makes analogs through the established synthetic routes and extends this work to structure–activity relationship studies.
MembersFaculty
The members of the Natural Products Chemistry Lab consist of faculty members, researchers, doctoral, master's, and undergraduate students, and a secretary.As of 2026
- ProfessorSatoshi Yokoshima
- Assistant ProfessorNariyoshi Umekubo
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Fume hood contains chemicals” Rayhana Alhour / CC0 (cropped)
- Total synthesis of natural products: “Prentice Hall Molecular Model Set for General Organic Chemistry 8139” Bin im Garten / CC BY-SA 3.0 (cropped)
- Development of new synthetic methodologies: “Round bottom flask 1” Stephanie cheks / CC BY-SA 4.0 (cropped)
- Design and synthesis of compounds for drug discovery: “ADAR Protein” Csully222 / CC BY-SA 4.0 (cropped)
- Related lab (Bioorganic Chemistry Lab): “Rotary evaporator” Waag Society from Amsterdam, The Netherlands / CC BY 2.0 (cropped)
- Related lab (Natural Products Chemical Biology Lab): “LABORATORY SCENES IN CHEMISTRY LABORATORY AND INSTRUMENT RESEARCH LABORATORY IRL BASEMENT - NARA - 17451414” Martin Brown / Public domain (cropped)
- Related lab (Integrative Organic Chemistry Lab): “Laboratory scientist conducts an experiment with a Rotary evaporator” National Eye Institute / CC BY 2.0 (cropped)
- Related lab (Animal Cell Physiology Lab): “US Navy 111215-N-PO203-033 Lt. Denis Colomb, principal investigator with Navy Experimental Diving Unit, prepares cell cultures” U.S. Navy photo by John F. Williams / Public domain (cropped)
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