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Perinatal and Maternal-Child Medicine Lab (Hospital: Comprehensive Perinatal and Maternal-Child Medical Center)
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The lab investigates the mechanisms of perinatal brain injury and explores treatments for it.
AboutAbout the lab
Exploring treatments and mechanisms that protect the newborn brain
The Perinatal and Maternal-Child Medicine Lab works in the neonatal division of the Comprehensive Perinatal and Maternal-Child Medical Center, where it engages in clinical work and research in neonatal neurology in addition to caring for newborns.
It also provides advanced care that requires extracorporeal membrane oxygenation and therapeutic hypothermia, and is equipped with cerebral function monitoring devices, MRI, and other equipment.
In its research, the lab addresses perinatal brain injury and neurological impairment associated with fetal growth restriction, and examines the effects of stem cell–based treatments and drugs.
It also studies how drugs used in the NICU affect the immature brain (the research descriptions and publication records cover work up to around 2016).
Key terms
- Perinatal brain injury
- Brain injury that occurs in babies around the time of birth. The development of new treatments is urgently needed.
- Stem cell therapy
- A form of regenerative medicine and cell therapy that uses stem cells to try to repair damaged tissue.
- Fetal growth restriction
- A condition in which fetal growth is delayed, caused by conditions such as hypertensive disorders of pregnancy. It can cause neurological sequelae after birth.
ResearchResearch themes
The lab investigates the mechanisms by which brain injury in newborns and fetal growth restriction affect the nervous system after birth, and explores ways to prevent and treat them. Using animal models and cultured neurons, it tests the effects of stem cells and drugs.
*Illustrative imageStem cell therapy for perinatal brain injury
Using a rat model, the lab showed that simultaneous administration into the brain of neural stem cells cultured from fetal brain and a chondroitin sulfate–degrading enzyme is an effective treatment. It has also conducted animal experiments with umbilical cord blood stem cells, and phase I clinical trials have begun in Japan.
*Illustrative imageNeurological impairment from fetal growth restriction
Using a model created by giving synthetic thromboxane A2 to the dam, the lab confirmed that fetal growth restriction caused by hypertensive disorders of pregnancy leads to delayed neurodevelopment and learning disabilities after birth. It is also developing ways to prevent and treat these effects.
*Illustrative imageNew drug treatments for perinatal brain injury
Glutamate excitotoxicity is involved in many neurological diseases, including perinatal hypoxic-ischemic encephalopathy. The lab found that chondroitin sulfate E protects neurons, and is examining other substances and drugs in animal models and cultured neurons.
*Illustrative imageEffects of NICU drugs on the immature brain
Many drugs are used in the NICU, but most of their effects on the immature brain are unknown. Studying both animal models and cell cultures, the lab showed in an animal model that dexamethasone causes neurological impairment even at a low dose.
MembersFaculty
The Perinatal and Maternal-Child Medicine Lab page lists faculty as its members.
- Hospital Associate ProfessorYoshiaki Sato
- Hospital LecturerYukako Muramatsu
- Assistant ProfessorToshihiko Suzuki
- Hospital Assistant ProfessorRyuichi Tanaka
- Assistant ProfessorKazuto Ueda
- Project Assistant ProfessorRyosuke Miura
- Hospital Assistant ProfessorAkinobu Taniguchi
- Hospital Assistant ProfessorTakashi Maeda
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Infant-Incubator-wBaby-1978-USA” Evan-Amos / Public domain (cropped)
- Stem cell therapy for perinatal brain injury: “The intensive therapy unit of the perinatal care center in Ryazan” KirillKoriakin / CC BY-SA 3.0 (cropped)
- Neurological impairment from fetal growth restriction: “Blood pressure measurement Manila CNE 01” CNEcija12345 / CC BY-SA 4.0 (cropped)
- New drug treatments for perinatal brain injury: “Leu-enkephalin molecule ball” Jynto (more from this user) / CC0 (cropped)
- Effects of NICU drugs on the immature brain: “Infusion pump 2” Senior Airman Andrea Posey/U.S. Air Force / Public domain (cropped)
- Related lab (Pediatric Surgery Lab): “Reserve Citizen Airmen build partnerships in operating room (8948139)” U.S. Air Force 94AW by Maj. Stephani Schafer / Public domain (cropped)
- Related lab (Otorhinolaryngology Lab): “Otoscope exam” U.S. Air Force photo by Senior Airman Christopher Toon / Public domain (cropped)
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