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Molecular Genetics Lab
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A lab that explores disease states such as cancer and aging through defects in DNA repair.
AboutAbout the lab
Exploring how diseases arise from defects in DNA repair.
The Molecular Genetics Lab studies the mechanisms of DNA repair and the diseases that result from the accumulation of DNA damage.
Cells repair damaged DNA to keep the genome stable, and when this function breaks down, it is involved in disease states such as cancer and aging.
Using next-generation genome analysis technologies, the lab aims to detect DNA damage, identify the causes of diseases, and develop diagnostic and therapeutic methods.
The lab welcomes young people who aspire to become researchers, as well as physicians.
Key terms
- DNA repair
- A cellular mechanism that repairs damaged DNA. When it fails, it is involved in disease states such as cancer and aging
- Transcription-coupled DNA repair
- A mechanism that rapidly removes DNA damage arising in the transcribed regions of genes, keeping the expression of genetic information stable
- Next-generation genome analysis
- Cutting-edge genome analysis technology known as NGS (next-generation sequencing). It is used to detect DNA damage in vivo and to identify the causes of disease
NewsLab news
Paper published in Nature Structural & Molecular Biology
Paper accepted by JCI and also selected for the journal cover
Professor Yuka Nakazawa received an award recognizing top leaders among women researchers
ResearchResearch themes
The lab investigates the DNA damage response and DNA repair mechanisms that keep genetic information stable, and uses its findings to deepen the understanding of disease states such as cancer and aging. By advancing both basic research and clinical application, it aims to contribute to establishing diagnostic and therapeutic methods for rare diseases caused by defective DNA repair.
*Illustrative imageTranscription-Coupled DNA Repair and Disease
The lab focuses on the mechanism of "transcription-coupled DNA repair," which rapidly removes DNA damage arising in the transcribed regions of genes. Defects in this mechanism cause hereditary diseases characterized by predisposition to cancer or premature aging.
*Illustrative imageInvestigating Disease with Next-Generation Genome Analysis
Centered on core next-generation genome analysis technologies, the lab has analytical techniques that can be used to detect DNA damage in vivo and to identify the causes of disease. Working with international collaborators and patient family associations, it hopes to contribute to establishing diagnostic and therapeutic methods for rare diseases caused by defective DNA repair.
MembersFaculty
The members of the Molecular Genetics Lab consist of faculty, doctoral students, technicians, an art designer, and a secretary.As of 2026
- ProfessorYuka Nakazawa
- Project Associate ProfessorHironobu Morinaga
- LecturerMikako Ito
- Project Assistant ProfessorKotaro Tsukada
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Elektrof” Stefan Walkowski / CC BY-SA 4.0 (cropped)
- Transcription-Coupled DNA Repair and Disease: “DNA Repair” Tom Ellenberger, Washington University School of Medicine in St. Louis. / Public domain (cropped)
- Investigating Disease with Next-Generation Genome Analysis: “DNBSEQ-T7” RPSkokie / CC BY-SA 4.0 (cropped)
- Related lab (Gastroenterological Surgery Lab): “Quirófano robótico” Hospitalhoms / CC BY-SA 4.0 (cropped)
- Related lab (Tumor Biology (Molecular Pathology) Lab): “Laboratory (2)” Linda Bartlett (Photographer) / Public domain (cropped)
- Related lab (Community Medical Education Lab): “Hainan Medical College - 13” Anna Frodesiak / CC0 (cropped)
- Related lab (Nagoya University Menard Collaborative Research Lab): “Laboratory microbiological shaker with cultures-01” real name: Matylda Sęk pl.wiki: Cygaretka commons: Cygaretka / CC BY-SA 3.0 (cropped)
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