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Cell Biology Lab
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A lab that studies cell adhesion and the movement of biological membranes at the molecular level.
AboutAbout the lab
Exploring cell adhesion and membrane dynamics at the molecular level
The lab studies how cells adhere and how biological membranes move.
One focus is the hemidesmosome, which attaches epithelial tissue to the basement membrane. Using mainly cultured cells derived from the epidermis, the lab investigates how hemidesmosomes are formed and disassembled.
The other focus is the liposome, an artificial membrane vesicle. The lab observes liposomes under an optical microscope to examine how biological factors such as the cytoskeleton affect membrane deformation.
Key terms
- Hemidesmosome
- An adhesion protein complex that attaches epithelial tissue to the basement membrane
- Basement membrane
- A matrix structure directly beneath epithelial sheets. Epithelial tissue is firmly attached to it so that it does not peel off
- Liposome
- A small sac made of artificial membrane, used as the simplest model of a biological membrane
ResearchResearch themes
Cell adhesion is an essential function for multicellular organisms. The lab investigates how adhesion structures are formed and disassembled, and also uses liposomes to understand, at the molecular level, the membrane movements that underlie cell shape and motility.
*Illustrative imageFormation and Disassembly of Hemidesmosomes
The lab studies the hemidesmosome, an adhesion structure that attaches epithelial tissue to the basement membrane, mainly in cultured cells derived from the epidermis. It aims to clarify how hemidesmosomes are formed and disassembled, including their links to disease.
*Illustrative imageMembrane Dynamics Seen Through Liposomes
The lab observes liposomes in real time under an optical microscope to study deformations such as fusion, fission, perforation, and turning inside out. By applying the cytoskeleton, molecular motors, and other factors to liposomes, it aims to understand the mechanisms responsible for cell shape and motility.
MembersFaculty
- LecturerYoshiaki Hirako
- LecturerKingo Takiguchi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Indian Muntjac fibroblast cells ( )” ZEISS Microscopy from Germany / CC BY 2.0 (cropped)
- Formation and Disassembly of Hemidesmosomes: “Cell junctions types shown on epithelial cells including cell-cell and cell-matrix junctions” Lu.qianhe / CC BY-SA 4.0 (cropped)
- Membrane Dynamics Seen Through Liposomes: “Phosphatidylcholine liposomes at phase-contrast microscopy” ArkhipovSergey / CC BY-SA 4.0 (cropped)
- Related lab (Microbial Motility Lab): “Microbiology techniques 1” Luis Fernando Flores LAB / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Modification and Regulation Lab): “VOYAGER adjustable tip spacing pipette” Labrat879 / CC BY-SA 4.0 (cropped)
- Related lab (Genetics Lab): “Culture vials of Drosophila melanogaster in Unifei” Mateus S. Figueiredo / CC BY 4.0 (cropped)
- Related lab (Cell Spatiotemporal Control Lab): “Elodea cells under microscope” ~delta / CC BY-SA 4.0 (cropped)
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