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Biocybernetics Lab
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The lab studies biocybernetics, using nanotechnology to rebuild and extend the mechanisms of living organisms.
AboutAbout the lab
Does function follow form?
The Hoshino-Maruyama Lab aims to understand the functions of living organisms through engineering technologies that control shape.
The lab studies how to rebuild and extend biological systems by applying, in an engineering way, physical phenomena shared by the autonomous movement and computation mechanisms of living organisms.
Based on the science of nano- and microstructures and on biological information processing, the lab investigates how biological functions are formed.
It applies the results to tissue regeneration engineering and to the development of interfaces that connect with living bodies.
Key terms
- Virtual electrode
- An electrode that is temporarily created where an electron beam is applied. Its shape and position can be freely changed by computer
- Mixed reality
- A technology that overlays and connects information inside a computer with the real world
- LAMP method
- A method that can rapidly amplify a target gene just by keeping the temperature constant (loop-mediated isothermal amplification). It is used for genetic testing
NewsLab news
Announced a display that lets a computer freely control nanoscale bumps and dips
Announced a method that uses AI to create new microstructures like those on plant surfaces
Announced a new technology that turns a flat surface into a three-dimensional shape using the pulling force of cells
A master's student won the Best Presentation Award at the Japan Society for Precision Engineering Spring Meeting
Associate Professor Maruyama and students won the SI2025 Outstanding Presentation Award from the Society of Instrument and Control Engineers
ResearchResearch themes
The lab aims to rebuild and extend biological systems by using, in an engineering way, physical phenomena found in the autonomous movement and computation mechanisms of living organisms. Building on the science of nano- and microstructures and on biological information processing, it studies technologies for manipulating molecules and cells, and devices for medicine.
*Illustrative imageA virtual electrode display for manipulating molecules
The lab aims to create "molecular-scale mixed reality," in which electric fields are projection-mapped onto real molecules to freely extend how molecules function. It has succeeded in manipulating nanoparticles in real time by scanning an electron beam at high speed to create force fields.
*Illustrative imageGuiding cell movement with shape
Changing how the boundary of a step is curved changes whether cells go down the step. Using this property, the lab studies a method that autonomously arranges the distribution of cells with different mobility through shape alone, aiming for application to tissue regeneration.
*Illustrative imageDevices for fast and simple genetic testing
The lab studies microfluidic devices with channels that automatically divide a tiny amount of liquid into many small chambers. Combined with the LAMP method, these devices test for the genes of viruses, food allergens, and other targets all at once.
MembersFaculty
The members of the Hoshino-Maruyama Lab are faculty, technical staff, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorTakayuki Hoshino
- Associate ProfessorHisataka Maruyama
- Assistant ProfessorDaigo Natsuhara
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Observing cell lines under microscope in a cell culture lab” Pinky9697 / CC BY-SA 4.0 (cropped)
- A virtual electrode display for manipulating molecules: “Scanning electron microscope - UFCH JH (2020) 01” Tadeáš Bednarz / CC BY-SA 4.0 (cropped)
- Guiding cell movement with shape: “HaCaT Cells Phase Contrast” Accuratelibrarian / CC BY-SA 4.0 (cropped)
- Devices for fast and simple genetic testing: “Thermal cycler for PCR” Juan Carlos Fonseca Mata / CC BY-SA 4.0 (cropped)
- Related lab (Intelligent Robotics Lab): “Pepper the Robot” Softbank Robotics Europe / CC BY-SA 4.0 (cropped)
- Related lab (Fluid System Engineering Lab): “Microfluidic Chip iX-factory” IX-factory STK / CC BY-SA 3.0 (cropped)
- Related lab (Cyber Robotics Lab): “Controlling robotic arm ESA15746126” European Space Agency / CC BY-SA 3.0 igo (cropped)
- Related lab (Biomechanics Lab): “Biaxial tensile machine” Lucaintro / CC BY-SA 4.0 (cropped)
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