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Functional Materials Creation Engineering Lab (Shinichiro Fuse)
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This organic synthesis lab uses microflow synthesis to make pharmaceuticals faster and at lower cost.
AboutAbout the lab
Advancing synthetic chemistry to make drug discovery more efficient
The Fuse Lab studies new organic synthesis processes for making pharmaceuticals and other compounds.
Using microflow synthesis, in which solutions react while flowing through narrow channels, the lab mixes solutions in a few milliseconds and controls reactions precisely.
The lab is uncovering the value of fast reactions that are difficult to control in a flask and have therefore been overlooked.
By also using machine learning, theoretical calculations, and automated synthesis, the lab aims to deliver better pharmaceuticals faster, at lower cost, and with less waste.
Key terms
- Microflow synthesis
- A synthesis method in which solutions react while flowing through narrow channels with an inner diameter of 1 mm or less. Solutions can be mixed in a few milliseconds.
- Peptide
- A molecule made of several amino acids linked together. It is also attracting attention as a pharmaceutical.
- Bayesian optimization
- A machine learning method that chooses the next conditions to try based on previous experimental results, searching for the best conditions in a small number of trials.
NewsLab news
A master's student received the Excellent Presentation Award at the Carotenoid Young Researchers' Meeting
A paper from joint research with Yokogawa Electric Corporation has been accepted for publication in ChemistryEurope
A doctoral student received the Nagoya University Academic Encouragement Award for fiscal 2026
A highlight review by a doctoral student has been accepted for publication in Chemistry Letters
A student received the Student Excellent Presentation Award at the 146th Annual Meeting of the Pharmaceutical Society of Japan
ResearchResearch themes
The lab aims to develop innovative organic synthesis processes that make possible what was previously impossible, by combining engineering technologies such as flow synthesis and automated synthesis with machine learning and theoretical calculations. Through innovation in synthetic organic chemistry, it aims to contribute to drug discovery science by delivering better pharmaceuticals faster, at lower cost, and with less waste.
*Illustrative imageSynthesis of peptides and amino acid derivatives
The lab has shown that peptides can be synthesized in good yield, even with inexpensive reagents that generate little waste, by precisely controlling the reaction time to less than a few seconds with microflow synthesis. It is also developing methods to produce N-methylated peptides, which are attracting attention as pharmaceuticals, and their cyclic peptides, quickly and at low cost.
*Illustrative imageSubstitution at the carbon adjacent to an aromatic ring
This research induces substitution reactions at the carbon next to aromatic rings such as indole rings, which are common in pharmaceuticals. Even for reactions in which side reactions are extremely fast and the desired product cannot be obtained in a flask, the lab controls activation and reaction on a millisecond scale to achieve high yields.
*Illustrative imageSynthesis of organophosphorus compounds
Phosphate triesters are used in pharmaceuticals, flame retardants, and other products, but the starting material, phosphorus trichloride, is so highly reactive that linking three different alcohols one after another was difficult. The lab has achieved this in high yield with microflow synthesis and is also working on synthesizing compounds with uniform stereochemistry at the phosphorus atom.
*Illustrative imageMachine learning and theoretical calculations
The lab uses Bayesian optimization to search for reaction conditions, finding the desired conditions with few experiments. For fast, exothermic reactions, it also aims to elucidate reaction mechanisms by comparing highly reliable data obtained with microflow synthesis against DFT calculations.
MembersFaculty
The Fuse Lab consists of faculty, administrative assistants, researchers, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorShinichiro Fuse
- Assistant ProfessorNaoto Yamasaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Uniqsis-FlowSyn Flow Reactor” Martyn Fordham / Public domain (cropped)
- Synthesis of peptides and amino acid derivatives: “Solid Peptide Synthesis reactor” Rudyher27 / CC BY-SA 4.0 (cropped)
- Substitution at the carbon adjacent to an aromatic ring: “Indole-3D-balls-2” Jynto (talk) / CC0 (cropped)
- Synthesis of organophosphorus compounds: “Organophosphorus labelled italian” Albris, based upon work by Stéphane Mons. / CC BY-SA 3.0 (cropped)
- Machine learning and theoretical calculations: “Fume hood MB” Miha Bukleski / CC BY 4.0 (cropped)
- Related lab (Process Informatics Engineering Lab): “Pueblo Chemical Agent-Destruction Pilot Plant Process Cooling Towers ( )” PEO ACWA / CC BY 2.0 (cropped)
- Related lab (Functional Materials Creation Engineering Lab (Asahi)): “Beta-Barium Orthotitanate crystal structure” WilliamDParker / CC BY-SA 3.0 (cropped)
- Related lab (Interface and Reaction Dynamics Lab): “Plasma creation” AngeloBi / CC BY 4.0 (cropped)
- Related lab (Crystal Growth Information Engineering Lab): “Rounded Silicon Carbide Ingot (cropped)” LaMèreVeille / CC BY-SA 4.0 (cropped)
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