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Biological Systems Engineering Lab
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A lab that studies microbes, from the outer structures of their cells to water treatment and fermentation.
AboutAbout the lab
Building engineering from living organisms as they actually live.
The Biological Systems Engineering Lab views living organisms as dynamic entities that are alive, and aims to shape engineering based on this dynamic and healthy picture of life.
Its research keywords are glycoconjugates, applied biochemistry, and environmental biotechnology.
Using methods such as biochemistry and molecular biology, the lab investigates the structures outside cells, useful enzymes, and microbial communities involved in water treatment and fermented foods.
The lab is also known as the Takeda Lab, and belongs to the Bio Education Program of the Department of Chemistry and Life Science, Faculty of Science and Engineering.
Key terms
- Sheathed bacteria
- Microbes that form a filamentous structure called a "sheath" on the outside of their cells and live inside it
- Complex microbial community
- A system in which multiple microbes gather and function together. It is used in bioprocesses such as water treatment and the production of fermented foods
- Next-generation sequencing
- A technology for obtaining large amounts of data (big data) to investigate the behavior of microbial communities
ResearchResearch themes
The lab investigates the sheath structures produced by sheathed bacteria, useful enzymes, and microbial communities involved in water treatment and fermented foods. Using methods such as biochemistry, molecular biology, and biochemical engineering, it seeks to clarify, for example, how structures on the outside of cells are formed.
*Illustrative imageStructural analysis of sheaths of sheathed bacteria
The lab analyzes the structures of the polysaccharide and peptide portions, and the biosynthetic genes, of the sheaths of sheath-forming filamentous bacteria, which cause problems in wastewater treatment systems. It also studies the mechanism of copper biosorption and enzymes that degrade the sheath.
*Illustrative imageResearch on novel useful enzymes
Using methods from microbiology, culture engineering, and molecular biology, the lab studies microbes that can produce cellulose and marine algae capable of producing useful substances. It also works on the purification and production of enzymes that distinguish between enantiomers of polymers.
*Illustrative imageAnalysis of complex microbial communities in water treatment and fermented foods
The lab is developing methods to investigate the activity of complex microbial communities that function in water treatment and the production of traditional fermented foods, using large amounts of data obtained by next-generation sequencing. With these methods, it tracks the behavior of individual microbes in settings such as groundwater remediation.
MembersFaculty
The Biological Systems Engineering Lab consists of faculty members and students at the doctoral, master's, and undergraduate levels.As of 2022
- ProfessorMinoru Takeda
- LecturerIchiro Suzuki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Making probiotics cabbage carrot” Zenyrgarden / CC BY-SA 4.0 (cropped)
- Structural analysis of sheaths of sheathed bacteria: “Physical model of a bacterial flagellum” Alan Wolf / CC BY-SA 2.0 (cropped)
- Research on novel useful enzymes: “Bacillus anthracis - CapD protein crystal structure” Argonne National Laboratory / CC BY-SA 2.0 (cropped)
- Analysis of complex microbial communities in water treatment and fermented foods: “La Crosse wastewater treatment facility-2” Wikideas1 / CC0 (cropped)
- Related lab (Biophysical Chemistry and Structural Life Chemistry Lab): “ANKRD35 protein structure” 1. Yang Zhang. I-TASSER: Fully automated protein structure prediction in CASP8. Proteins, 77 (Suppl 9): 100-113, 2009. 2. Ambrish Roy, Jianyi Yang, Yang Zhang. COFACTOR: an accurate comparative algorithm for structure-based protein function annotation. Nucleic Acids Research, 40: W471-W477, 2012. 3. Jianyi Yang, Yang Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015. / CC BY-SA 4.0 (cropped)
- Related lab (Nittami Lab): “Secondary treatment reactors - Blue Plains WWTP - 2016b” Moreau1 / Public domain (cropped)
- Related lab (Organic Electrochemistry Lab): “Conjure Segmented Flow Chemistry System” Jankhughes / CC BY-SA 3.0 (cropped)
- Related lab (Aramaki Lab): “Dülmen, Dernekamp, Seifenblase” Dietmar Rabich / CC BY-SA 4.0 (cropped)
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