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Organic Synthetic Chemistry Lab
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A synthetic chemistry lab that creates organic compounds with biological activity or useful functions.
AboutAbout the lab
Designing molecules and exploring effective synthetic methods.
The Organic Synthetic Chemistry Lab studies methods for synthesizing bioactive organic compounds and functional organic compounds that enrich daily life.
Because new reactions are essential for making target compounds, the lab develops highly selective synthetic methods, works on asymmetric synthesis, and searches for new reactions.
The lab started in April 2021 as the Hoshino Lab.
On the lab's website, it is presented under the name "Hoshino Lab."
Key terms
- o-quinone methide
- A highly reactive species with only a momentary lifetime. This lab generates it from phenols.
- Heterocycle
- A ring structure that contains elements other than carbon, such as oxygen, sulfur, or nitrogen.
- Terpene
- A class of compounds that gives rise to the aroma molecules found in forest bathing, fragrances, and aromatherapy.
ResearchResearch themes
The lab studies synthetic methods for efficiently producing bioactive organic compounds needed to sustain human life, as well as functional organic compounds that enrich daily life. It sets specific target compounds in line with the needs of society and searches for new reactions. The research description on the lab website dates from around 2021.
*Illustrative imageHeterocycle synthesis using o-quinone methides
The lab is investigating how to efficiently synthesize natural products containing heterocyclic structures. The approach is to easily generate o-quinone methide, a reactive species with only a momentary lifetime, from phenols and use it in cyclization reactions.
*Illustrative imageSynthesis of analogues of bioactive natural products
Natural compounds with distinctive biological activity, such as anticancer activity, may become new drugs. To enhance this activity, the lab designs and synthesizes analogues with partially modified structures.
*Illustrative imageEnvironmentally friendly new rearrangement reactions
The lab is devising a new rearrangement reaction that produces no by-products and achieves carbon chain elongation and control of double bond geometry at the same time. It uses this reaction to study the synthesis of terpenes with defined stereostructures.
*Illustrative imageDesign and synthesis of new functional materials
By using fluorine–carbon bonds in liquid crystal molecules, the lab has succeeded in synthesizing liquid crystal compounds with excellent properties. It is now searching for efficient synthetic methods and for compounds with even better physical properties through computer-aided molecular design.
MembersFaculty
The members of the Organic Synthetic Chemistry Lab consist of faculty members, master's students, and undergraduate students.As of 2026
- ProfessorYujiro Hoshino
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Standard Schlenk flask” OMCV / Public domain (cropped)
- Heterocycle synthesis using o-quinone methides: “Chemistry Laboratory, Augustine University, Ilara Epe” Addjimedu / CC0 (cropped)
- Synthesis of analogues of bioactive natural products: “Medicinal plants in khafr-Isfahan-Iran گل ها و گیاهان دارویی در روستای خفر پادنا از توابع استان اصفهان 09” Mostafameraji / CC BY-SA 4.0 (cropped)
- Environmentally friendly new rearrangement reactions: “Schlenk flask 500mL” Ichwarsnur / CC BY-SA 4.0 (cropped)
- Design and synthesis of new functional materials: “Organic home-grown tomatoes - unripe to ripe” Michal Klajban / CC BY-SA 4.0 (cropped)
- Related lab (Organic Electrochemistry Lab): “Conjure Segmented Flow Chemistry System” Jankhughes / CC BY-SA 3.0 (cropped)
- Related lab (Physical Organic Chemistry and Molecular Design Lab): “Chlorophacinone-3D-molecular-model-engraved-render-CAS” MolGod Scientific / CC BY-SA 4.0 (cropped)
- Related lab (Biophysical Chemistry and Structural Life Chemistry Lab): “ANKRD35 protein structure” 1. Yang Zhang. I-TASSER: Fully automated protein structure prediction in CASP8. Proteins, 77 (Suppl 9): 100-113, 2009. 2. Ambrish Roy, Jianyi Yang, Yang Zhang. COFACTOR: an accurate comparative algorithm for structure-based protein function annotation. Nucleic Acids Research, 40: W471-W477, 2012. 3. Jianyi Yang, Yang Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015. / CC BY-SA 4.0 (cropped)
- Related lab (Photofunctional Chemistry Lab): “Optical photochromic lenses” Albarubescens / CC BY-SA 4.0 (cropped)
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