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Akimoto Lab
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A lab that studies, at the molecular level, how exercise changes skeletal muscle.
AboutAbout the lab
Exploring at the molecular level why exercise changes muscle.
The Akimoto Lab studies at the molecular level how skeletal muscle changes in response to exercise.
It investigates how the forces applied to muscle, and RNAs that do not code for proteins, change the properties of muscle.
The lab aims to clarify, through the underlying mechanisms, why exercise is good for health, and also addresses links to aging and lifestyle-related diseases.
It conducts many joint studies with universities in Japan and abroad, and its results are published in international journals.
Key terms
- Skeletal muscle
- Muscle used to move the body. Its thickness and properties change with exercise and aging.
- Mechanical stress
- Force applied to cells and tissues. Stretching, contraction, and tension during exercise are examples.
- Non-coding RNA
- RNA that is not a template for proteins. It regulates how genes function.
NewsLab news
A joint study with Osaka University is published in Nature Communications
A joint study with Osaka University is published in Skeletal Muscle
A joint study with Osaka University is published in Nature Cell Biology
A joint study with Mie University is published in Journal of Cachexia, Sarcopenia and Muscle
An international joint study is published in International Journal of Mental Health and Addiction
ResearchResearch themes
The lab clarifies, at the cellular and molecular level, the mechanisms by which skeletal muscle changes in response to exercise and environment. It also pursues the mechanisms behind the health benefits of exercise.
*Illustrative imageMuscle Changes Caused by Force
The lab investigates how the force applied to muscle during exercise (mechanical stress) changes the mass and properties of skeletal muscle.
*Illustrative imageNon-coding RNA and Muscle
The lab studies how RNAs that do not code for proteins, such as microRNAs, are involved in changes in skeletal muscle in response to exercise.
*Illustrative imageWhy Exercise Is Good for Health
The lab seeks to explain the beneficial effects of exercise on the body in terms of molecular action. It addresses the improvement of insulin resistance and the relationship with how quickly aging progresses.
*Illustrative imageEngineering Skeletal Muscle Tissue
Using tissue engineering methods, the lab works on creating three-dimensional skeletal muscle tissue from cultured cells.
MembersFaculty
- ProfessorTakayuki Akimoto
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Muscle Tissue Skeletal Muscle Fibers ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Muscle Changes Caused by Force: “Trap bar with load” RickyBennison / CC0 (cropped)
- Non-coding RNA and Muscle: “G riboswitch RNA ribbon” Jane & David Richardson / CC BY 3.0 (cropped)
- Why Exercise Is Good for Health: “Insulincrystals” NASA/Marshall / Public domain (cropped)
- Engineering Skeletal Muscle Tissue: “3D printed Hydrogel Scaffold” Habannn / CC0 (cropped)
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- Related lab (前田研究室): “Elastic artery seen in a histological section” Otávio Astor Vaz Costa / CC BY 4.0 (cropped)
- Related lab (宮本研究室): “Tendon - intermed mag” Nephron / CC BY-SA 3.0 (cropped)
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