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Yagi Lab
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The lab uses experiments to trace the path by which proteins came into being.
AboutAbout the lab
Retracing protein evolution through experiments
The Yagi Lab studies the structure and evolution of proteins.
It recreates and tests in experiments how life came to acquire the proteins it has today.
The lab works on creating three-dimensional structures from short peptides made of only a few kinds of amino acids.
It also studies how properties have changed over time by reconstructing ancestral proteins.
Key terms
- Protein
- A molecule made of linked amino acids. It takes a specific three-dimensional shape to function
- Peptide
- A short chain of a small number of linked amino acids, shorter than a protein
- Ancestral protein reconstruction
- Comparing the proteins of present-day organisms to infer their ancient forms, and then actually producing them
NewsLab news
Reported from the reconstruction of ancestral enzymes that abrupt global cooling drove enzyme evolution
Discovered a new protein structure that serves as an evolutionary link, published in Nature Communications
ResearchResearch themes
The lab studies how the three-dimensional structures of proteins arose and branched out during evolution. In collaboration with RIKEN, it is working on recreating evolution in experiments.
*Illustrative imageRecreating the evolution of protein structure
The lab found that short peptides with the same sequence can form different three-dimensional structures depending on the surrounding conditions. Using this as a clue, it recreates in experiments the path by which the structures of proteins involved in gene function branched out.
*Illustrative imageReconstructing ancestral enzymes
The lab traces evolution back from the enzymes of present-day organisms to reconstruct ancestral enzymes. It then studies how their properties, such as adaptation to temperature, have changed.
MembersFaculty
- Sota Yagi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “PhylogeneticTree, Woese 1990” Maulucioni / CC BY-SA 3.0 (cropped)
- Recreating the evolution of protein structure: “Crystalized green fluorescence protein (GFP)” Honestresearcher / CC BY-SA 4.0 (cropped)
- Reconstructing ancestral enzymes: “Glacier with ice rocks on ground” U.S. Fish and Wildlife Service / Public domain (cropped)
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- Related lab (平塚研究室): “CSIRO ScienceImage 3830 Tropical rainforest canopy near Cairns QLD” Willem van Aken, CSIRO / CC BY 3.0 (cropped)
- Related lab (松本研究室): “Salt Lake City smog haze skyline 01” Eltiempo10 / CC BY-SA 4.0 (cropped)
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