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Bannai Lab
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The lab reads the workings of the brain from the behavior of molecules.

AboutAbout the lab
Even as its parts are replaced, the brain remains the brain
The Bannai Lab aims to elucidate how the brain works and how neurological diseases develop, using nanoscale biological information on the structure, function, and dynamics of the protein molecules that make up living organisms.
The brain, which processes enormous amounts of information, is often compared to a computer, but a major difference is that the proteins and lipids that make up the brain are constantly replaced throughout life.
The lab asks how the brain's structure is maintained while its components are replaced, and how it can still carry out higher functions such as memory, learning, and thought.
Under the banner of "nanoscale biology," the lab aims to connect biology, semiconductor nanotechnology, medicine, and informatics.
Key terms
- Single-molecule imaging
- An observation method in which molecules are made to glow one at a time so that their movements inside living cells can be tracked
- Synapse
- The junction where neurons pass information to each other. It is the basis of memory and learning
- Quantum dot
- A semiconductor particle a few nanometers across. It glows brightly for a long time in a color that depends on its size, so it can be used to label molecules
NewsLab news
A master's student won a Gold Medal in the poster awards of Special Exercise A in the Department of Electrical Engineering and Bioscience
A master's student won an Excellent Presentation Award at the early-career researchers' session (Wakate Dojo) of Neuro2026
A master's student won the Best Oral Presentation Award at the 204th Annual Meeting of the Franco-Japanese Society of Biology
Master's and doctoral students won CSH Fellowships at a Cold Spring Harbor Asia conference
A master's student won a Student Excellent Presentation Award at the Pharmaceutical Society of Japan's PH Symposium
ResearchResearch themes
By "observing" the structure, function, and dynamics of protein molecules in living cells, the lab aims to elucidate the mechanisms of memory and learning and the pathology of neurological diseases such as epilepsy and Alzheimer's disease. Its research rests on three pillars: physiological research, pathological research, and development of new technologies.
*Illustrative imagePhysiological research
How are synapses, the basis of memory and learning, formed, maintained, and regulated? To understand the molecular mechanisms, the lab visualizes how synaptic molecules move and where they accumulate inside living neurons.
*Illustrative imagePathological research
To clarify the mechanisms by which neurological diseases such as Alzheimer's and Parkinson's disease develop, the lab examines how pathological tau, amyloid β, and α-synuclein affect the structure and function of synapses.
*Illustrative imageDevelopment of new technologies
To visualize and manipulate biomolecules in living cells, the lab develops new experimental tools based on the latest findings in biophysics. Examples include developing probes that make denatured tau visible and establishing methods to analyze large volumes of single-molecule movement data with machine learning.
MembersFaculty
The Bannai Lab consists of faculty members, research assistants, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorHiroko Bannai
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Synapsin and CamK2 positive neurons” ManuelSchottdorf / CC BY-SA 4.0 (cropped)
- Physiological research: “Нейрон коры с множеством дендритных шипиков” Sergb95 / CC BY-SA 4.0 (cropped)
- Pathological research: “Histopathology of amyloid plaque in Alzheimer's disease” Mikael Häggström, M.D. / CC0 (cropped)
- Development of new technologies: “EFluor Nanocrystal Vials” Travis.jennings / CC BY 3.0 (cropped)
- Related lab (Takamatsu Lab): “Dictyostelium Late Aggregation 1” Bruno in Columbus / Public domain (cropped)
- Related lab (Kiga Lab): “Block tower on narrow base” Reseletti / CC0 (cropped)
- Related lab (Okano Lab): “Plastic-compass” Evan-Amos / Public domain (cropped)
- Related lab (Iwasaki Lab): “Cyanobacteria 029” Lamiot / CC BY-SA 3.0 (cropped)
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