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Yamaguchi Lab
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The lab links molecules, breaks them apart, and creates molecules never seen before.
AboutAbout the lab
Linking, breaking, and creating molecules: the three pillars of synthetic chemistry.
The Yamaguchi Lab is a synthetic organic chemistry lab that builds molecules, the smallest units of function.
Its research rests on three pillars: "linking molecules," "breaking molecules," and "creating innovative molecules."
The lab draws on methods from organometallic chemistry, total synthesis, photochemistry, structural organic chemistry, electrochemistry, medicinal chemistry, plant physiology, and chemical biology, without being confined by disciplinary boundaries.
Building on catalysts it has discovered independently, the lab aims to develop reactions that enable molecules to be constructed at will.
Key terms
- Cross-coupling
- A reaction that uses a catalyst to join the carbon atoms of two molecules.
- Direct transformation of carbon–hydrogen bonds
- A reaction that converts C–H bonds in a molecule directly into other bonds, without first installing a functional group.
- Dearomatization
- Deliberately breaking down a flat, stable ring such as a benzene ring to convert it into a three-dimensional framework.
NewsLab news
A master's student received the Excellent Presentation Award at the 90th Kanto Branch Symposium of the Society of Synthetic Organic Chemistry, Japan
The lab's Associate Professor received the 66th Encouragement Award from the UBE Foundation
A doctoral student received the 2025 Ono Azusa Memorial Award
A student in the lab received the 2025 Morimura Homeikai Encouragement Award
ResearchResearch themes
Molecules are the smallest units of function, and synthetic chemistry makes it possible to assemble them. Built on three pillars (linking molecules, breaking molecules, and creating innovative molecules), the lab takes on the challenge of constructing molecules at will, using catalysts and synthetic strategies it has discovered on its own.
*Illustrative imageLinking Molecules
Linking organic molecules requires reactions that form carbon–carbon bonds. The lab aims to extend cross-coupling, a method honored with a Nobel Prize, and to develop catalysts and reactions that enable free molecular construction.
*Illustrative imageBreaking Molecules
In making molecules, breaking bonds and forming bonds are two sides of the same coin. Believing that free molecular construction starts with cleaving the desired bond, the lab works on cleaving stable carbon–carbon bonds and on developing catalysts that then form new bonds from them.
*Illustrative imageCreating Innovative Molecules
The catalysts the lab develops are used to synthesize drug candidates and natural products. Its ultimate goal, however, goes further: to create functional molecules that are not yet known and to elucidate how they work.
MembersFaculty
The Yamaguchi Lab is made up of faculty members, administrative and technical assistants, doctoral, master's, and undergraduate students, and students assigned for seminar courses and research students.As of 2024
- ProfessorJunichiro Yamaguchi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Column chromatography - Feb. 2014” Максим Фомич / CC BY 2.0 (cropped)
- Linking Molecules: “Red jigsaw puzzle pieces 2” Profpcde / CC0 (cropped)
- Breaking Molecules: “Kintsugi on broken Kyūsu lid-bottom oblique PNr°1260” D-Kuru / CC BY-SA 4.0 (cropped)
- Creating Innovative Molecules: “Pills and medicines 01” BuhaM / CC BY-SA 4.0 (cropped)
- Related lab (Hosokawa Lab): “Green and yellow sea sponges, Antarctica” Steve Rupp, National Science Foundation / Public domain (cropped)
- Related lab (Sugahara Lab): “Nacre sticks” Mauro Cateb / CC BY-SA 3.0 (cropped)
- Related lab (Homma Lab): “Microcrystalls of nickel” Michał Milczarek / CC BY-SA 4.0 (cropped)
- Related lab (Umeno Lab): “Lysozyme Protein Crystal in Hanging-Drop Crystallization” Rohit Sharma / CC BY 4.0 (cropped)
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