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Yasuda Lab
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A lab that builds up cells from their components to read the "collective effects" of life through physics.
AboutAbout the lab
Understanding how life works in the language of physics
The Yasuda Lab seeks to understand how life works in the language of physics.
Living things are systems organized in a hierarchy from molecules to cells to individuals, and they show properties that do not arise by simply gathering molecules together.
In physics, observing regular behavior requires something on the order of Avogadro's number of elements, yet life maintains high regularity and reproducibility with only a handful of elements.
The lab investigates where this "collective effect" comes from, using a constructive approach that builds systems up from their elements.
Key terms
- Collective effect
- The emergence of regularity, when a small number of elements come together, that could not be predicted from the behavior of each element alone
- Constructive approach
- A method of rebuilding a target from its elements to verify how it works
- Biomolecular motor
- A tiny device made of biological molecules that converts chemical energy into movement
ResearchResearch themes
For each level of the hierarchy of life, the lab uses a constructive approach to clarify the behavior of a single unit and the collective effects that emerge when units come together. Its work ranges from single-molecule measurements of biomolecular motors, to networks of cardiomyocytes and neurons, to the development of drug discovery support technology using cell chips.
*Illustrative imageBiomolecular motors and myofibrils
The lab studies the single-molecule mechanisms of biomolecular motors, which convert chemical energy into mechanical energy. It also analyzes the collective oscillation phenomena shown by myofibrils, which form when these motors self-organize.
*Illustrative imageNetworks of cardiomyocytes and neurons
The lab compares the behavior of single cardiomyocytes or neurons with their behavior when assembled into a group with a defined spatial arrangement. From this, it approaches the cooperativity and collective effects of cell networks.
*Illustrative imageCell chips and drug discovery support
The lab has succeeded in building the smallest cell network chip, which can be called an "organ model." It is also developing drug discovery support technology using cardiomyocytes derived from human stem cells, and applications in drug screening are beginning.
MembersFaculty
- ProfessorKenji Yasuda
VoicesStudent voices
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Write a lab reviewAnonymous · Your draft is saved if you stopRelatedLabs similar to Yasuda Lab
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Yamada LabSchool of Advanced Science and Engineering, Department of PhysicsTheoretical astrophysicsThe information on this page is compiled by the LabLog team from the lab's public information and interviews. For corrections or removal requests, please contact LabLog, not the lab.
Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Hydrodynamic flow focusing in a microfluidic device” Ihor Panas / CC BY 4.0 (cropped)
- Biomolecular motors and myofibrils: “Muscle Tissue Skeletal Muscle Fibers ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Networks of cardiomyocytes and neurons: “Cardiac muscle histology 400x” Alexander G. Cheroske / CC BY-SA 4.0 (cropped)
- Cell chips and drug discovery support: “Рождение микрофлюидного чипа 2” Данилюк Валентина / CC BY-SA 4.0 (cropped)
- Related lab (Takano Lab): “Crowded cytosol” TimVickers / Public domain (cropped)
- Related lab (Ueda Lab): “Osteosarcoma cells stained for actin, microtubules, and nuclei” Howard Vindin / CC BY 4.0 (cropped)
- Related lab (Takayama Lab): “Si atoms in graphene ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- Related lab (Yamada Lab): “Keplers supernova” NASA/ESA/JHU/R.Sankrit & W.Blair / Public domain (cropped)
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