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Hoshino Lab
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A lab that explores how exercise changes skeletal muscle and adipocytes.
AboutAbout the lab
Understanding adaptation to exercise as a system.
The Hoshino Lab aims to clarify how the body responds and changes when we exercise: the phenomena, the mechanisms, and the system as a whole.
Currently, the lab focuses on skeletal muscle and adipocytes (fat cells).
Using mathematical modeling, the lab analyzes signal transduction, gene expression, and the dynamics of lactate concentration during exercise.
The lab conducts research and experiments in collaboration with the Kano Lab, which belongs to the same Chemical and Biological Engineering Program.
Key terms
- Skeletal muscle
- The muscle used to move the body. It is one of the targets in which this lab studies responses to exercise.
- Lactate
- A substance produced in the body. This lab studies how its concentration changes with exercise.
- Transcriptome
- A comprehensive analysis of the gene transcripts (RNA) being produced in cells.
NewsLab news
Doctoral and master's students received an Encouragement Award at the exercise physiology society's meeting
A paper by a student who completed the master's program was accepted by Physiological Genomics
A reply to a comment on a doctoral student's review article was published in Redox Biochemistry and Chemistry
A master's student received the Young Investigator Outstanding Presentation Award (Mitsuhashi Award) at the Skeletal Muscle Biology Research Meeting
A master's student received the Outstanding Presentation Award at the master's thesis presentation
ResearchResearch themes
This lab aims to open up an academic field called "exercise systems biology." It seeks to clarify how the body responds and changes when we exercise: the phenomena, the mechanisms, and the system as a whole.
Understanding adaptation to exercise as a system
The lab believes that, beyond studies that follow single molecules or statistically compare mean values, it is necessary to examine the structure and regulatory properties of molecular networks, the interactions between organs, and the whole picture through omics analysis. The lab hopes this will be a step toward understanding adaptation to exercise as a system.
*Illustrative imageResponses of skeletal muscle and adipocytes to exercise
Focusing on skeletal muscle and adipocytes, the lab analyzes signal transduction, gene expression, and the dynamics of lactate concentration during exercise using mathematical modeling. The lab is also advancing transcriptome analysis, in order to approach what is happening within the whole picture.
MembersFaculty
The members of the Hoshino Lab are faculty and doctoral, master's, and undergraduate students.As of 2026
- Associate ProfessorDaisuke Hoshino
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Skeletal muscle slide” علاء / CC BY-SA 3.0 (cropped)
- Responses of skeletal muscle and adipocytes to exercise: “Skeletal muscle1-es” The original uploader was Jeremykemp at English Wikipedia. / CC BY 4.0 (cropped)
- Related lab (Nakane Lab): “Microfluidic Device ( )” National Institute of Standards and Technology / Public domain (cropped)
- Related lab (Ueno Lab): “Propagation of light through the core of an optical fiber. Macro visualization.” AZToshkov / CC BY-SA 3.0 (cropped)
- Related lab (Kato Lab): “Frequency Comb ( )” National Institute of Standards and Technology / Public domain (cropped)
- Related lab (Sakano Lab): “CSIRO ScienceImage 2578 Preparing a Protein Crystal sample for Xray” North Sullivan Photography, CSIRO / CC BY 3.0 (cropped)
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