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Yamazaki Lab
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The lab simulates neural circuits of the brain on supercomputers.
AboutAbout the lab
Aiming for a digital copy of the brain on supercomputers.
The Yamazaki Lab studies neural circuits of the brain, using numerical computation and high-performance computing (HPC) as its foundational technologies.
Its research goal is to build biologically detailed models of neural circuits, in other words a digital copy of the brain.
To this end, the lab is developing Neulite, a simulator that runs such detailed models.
The lab especially welcomes students who want to move into brain research from the field of HPC.
Key terms
- Biologically detailed model
- A model of neural circuits that incorporates the spatial shape of individual neurons, the diffusion of current inside cells, and even the opening and closing of ion channels
- High-performance computing (HPC)
- Technology for performing large-scale numerical computation quickly, using supercomputers and similar systems
- Spiking neuron
- A neuron model that exchanges information by emitting signals called spikes
NewsLab news
View More ↗ResearchResearch themes
The lab aims to build biologically detailed models of neural circuits, in other words a digital copy of the brain. As a means to this end, it is developing Neulite, a simulator that runs detailed models.
*Illustrative imageA digital copy of the brain and simulator development
The goal is to build biologically detailed models of neural circuits, in other words a digital copy of the brain. As a means to this end, the lab is developing the simulator Neulite.
*Illustrative imageRunning the whole mouse cerebral cortex on Fugaku
The lab has succeeded in running a biologically detailed model of the whole mouse cerebral cortex on the full system of the supercomputer Fugaku. It believes that, as supercomputer performance improves, digital copies of the whole human cerebral cortex and the whole brain will become possible in the future.
*Illustrative imageResearch topics in simulator development
The current focus is the development of the simulator. Possible research includes introducing low-precision and mixed-precision computation schemes, developing parallel computing techniques for reaction-diffusion systems, and developing training methods for large-scale networks.
*Illustrative imageSimulation connecting the brain and the body
Students currently in the lab have built a mouse-scale cerebral cortex, basal ganglia, cerebellum, and thalamus with spiking neurons, and run them in real time on GPUs. On top of this, they implement hierarchical reinforcement learning and work on motor learning with a musculoskeletal model of a mouse body.
MembersFaculty
The members of the Yamazaki Lab consist of faculty, project researchers, industry-academia-government collaboration researchers, research support staff, visiting researchers, doctoral, master's, and undergraduate students, and research students.As of 2026
- ProfessorTadashi Yamazaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “RIKEN R-CCS Fugaku” Barsaka2 / CC0 (cropped)
- A digital copy of the brain and simulator development: “Simulation of hrose neuron” TjeerdB at English Wikipedia / CC BY 3.0 (cropped)
- Running the whole mouse cerebral cortex on Fugaku: “Mouse Brain (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Research topics in simulator development: “Columbia Supercomputer - NASA Advanced Supercomputing Facility” Trower, NASA / Public domain (cropped)
- Simulation connecting the brain and the body: “TOCABI black 3200px” Cadop / CC BY-SA 4.0 (cropped)
- Related lab (小山 大介 研究室): “Triangulation with edge midpoints” Grawiuton / CC0 (cropped)
- Related lab (山本
有作 研究室): “Extended Sparse Matrix” Yetanotherwikier / CC BY-SA 4.0 (cropped) - Related lab (龍野 智哉 研究室): “Lampe plasma deuxieme generation - simulation solaire” Lumieresuisse / CC BY-SA 3.0 (cropped)
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