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Seki Lab
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A lab that explores RNA folding with mathematical models.
AboutAbout the lab
Turning RNA folding into a tool for computation.
Seki Lab uses mathematical models to study the phenomenon in which RNA folds as it is being synthesized.
This model is called "Oritatami," and the lab aims to broaden the applications of RNA origami.
Oritatami is a new subject in a field that explores the design of self-assembly through the concepts of computation.
The lab's website introduces it under the name "ORITATAMI LAB."
Key terms
- Co-transcriptional folding
- The phenomenon in which the part of an RNA that has already been made begins to fold while the RNA is still being synthesized
- RNA origami
- An experimental mechanism in which a single RNA sequence folds as it is transcribed to form a nanoscale rectangular tile
- Self-assembly
- The phenomenon in which components bind to each other on their own and form a predetermined shape or structure
ResearchResearch themes
Oritatami is a mathematical model of co-transcriptional folding, in which RNA folds while it is being transcribed. The lab aims to broaden the applications of RNA origami and to understand how cells control RNA folding. Note that the research description on the lab website dates from around 2017.
*Illustrative imageCo-transcriptional Folding of RNA
RNA origami is a mechanism in which a single RNA strand folds as it is transcribed to form a nanoscale rectangular tile. Oritatami is a model that treats this folding mathematically.
*Illustrative imageAn Oritatami Binary Counter That Counts with RNA
Oritatami is not meant to predict RNA shapes; it is a model for building devices that compute using the order of folding. Together with collaborators, the lab proposed a binary counter.
MembersFaculty
The members of Seki Lab are faculty, a secretary, and master's and undergraduate students.
- Shinnosuke Seki
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “RNA secondary structure mascRNA” Ppgardne / CC BY-SA 3.0 (cropped)
- Co-transcriptional Folding of RNA: “Rna origami adaption” Perescameron / CC BY-SA 4.0 (cropped)
- An Oritatami Binary Counter That Counts with RNA: “DNA Origami Triangular” Matthias A. Fenner / CC BY-SA 4.0 (cropped)
- Related lab (小林 聡 研究室): “XBio illustration – DNA Origami” explorebiology / CC BY 4.0 (cropped)
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