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Torigoe Lab
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A lab that investigates how proteins and DNA recognize other molecules, by studying their structures and properties.
AboutAbout the lab
Uncovering how biomolecules recognize each other.
The Torigoe Lab studies life phenomena that arise when biomolecules such as proteins and DNA interact with other biomolecules, from the viewpoint of the chemistry of life.
The lab prepares biomolecules itself, analyzes their higher-order structures by spectroscopic methods, and examines the properties of interactions between molecules using thermodynamic, kinetic, and electrochemical methods.
It also investigates the functions of biomolecules using molecular biological and genetic methods.
The lab is an interdisciplinary one that takes a broad range of approaches centered on physical chemistry, biochemistry, molecular biology, and genetics, and it is introduced as open to anyone, whichever of these fields they are interested in.
Key terms
- Triplex nucleic acid
- A structure formed when a single-stranded nucleic acid binds to double-stranded DNA. It forms stably under acidic conditions but is unstable at neutral pH.
- Telomere
- The end region of a chromosome. It shortens as cells age and acts as a biological clock.
- Single nucleotide polymorphism (SNP)
- Subtle variation in DNA sequence from person to person. It is related to susceptibility to disease and to how well a drug works.
NewsLab news
View More ↗ResearchResearch themes
This lab aims to clarify how biomolecules distinguish their partners and bind to them, based on molecular structures and the properties of their interactions. Its research introduction covers studies on triplex nucleic acids, telomere DNA-binding proteins, and genome science.
*Illustrative imageTriplex nucleic acids and their binding proteins
The lab investigates methods for forming stable triplex nucleic acids even at neutral pH, and how proteins that bind to triplex nucleic acids recognize them. It aims to apply this to artificial control of gene expression and to drug discovery targeting oncogenes and similar genes.
*Illustrative imageTelomere DNA-binding proteins
The lab studies the three-dimensional structures of proteins that bind to telomere DNA, to clarify how they recognize DNA and how they interact with telomerase. It aims to elucidate the mechanisms of cellular senescence and carcinogenesis, and to apply this to artificial control of carcinogenesis.
*Illustrative imageGene function prediction and SNP detection
The lab is developing a method to predict the function of genes of unknown function by artificially activating or suppressing their expression, and a method to efficiently detect single nucleotide polymorphisms using specific binding between metal ions and DNA.
MembersFaculty
The members of the Torigoe Lab are faculty and master's and undergraduate students.As of 2019
- ProfessorHidetaka Torigoe
- Assistant ProfessorKei Hirabayashi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “DNA model Projected By Handmade Pyramid Hologram” MagzhanArtykov / CC BY-SA 4.0 (cropped)
- Triplex nucleic acids and their binding proteins: “Probable Nucleic Acid precipitated” michael / CC BY 2.0 (cropped)
- Telomere DNA-binding proteins: “Telomeres transparent” AJC1 / CC BY-SA 4.0 (cropped)
- Gene function prediction and SNP detection: “Preparing genotyping arrays” Daniel Sone (Photographer) / Public domain (cropped)
- Related lab (福井研究室): “ZeaSeedling” Douglas Goldman / CC BY-SA 4.0 (cropped)
- Related lab (川﨑研究室): “Discoveries from Asteroid Bennu- Media Briefing Graphics (SVS14772 - NASA Chiral Molecules V2)” NASA's Scientific Visualization Studio - NASA/Nicola Fox, Smithsonian Institution/Timothy McCoy, Natural History Museum, London/Sara Russell, NASA/GSFC/Daniel Glavin, NASA/GSFC/Jason Dworkin, NASA/GSFC/Rani Gran, eMITS/Dan Gallagher, Jacobs-JETS/Scott Eckley, Barrios Technology Ltd/Rachel Barry, ADNET Systems, Inc./Lonnie Shekhtman / Public domain (cropped)
- Related lab (石川研究室): “Scanning electron microscope view of iron crystal (S72-55208)” NASA Johnson Space Center / Public domain (cropped)
- Related lab (貞清研究室): “Potassium trisoxalatoiron(III) trihydrate in vial” EryZ / CC BY-SA 3.0 (cropped)
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