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Tsukakoshi Lab
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A nucleic acid chemistry lab that uses DNA aptamers to investigate the mechanisms of dementia.
AboutAbout the lab
The chemistry and applications of nucleic acid–protein interactions
The Tsukakoshi Lab studies "DNA aptamers," short single-stranded DNA molecules that interact strongly with specific target molecules.
The lab conducts basic research ranging from aptamer development to evaluation of their physical properties and structures, and applies it to elucidating the mechanisms behind the onset of dementia, including Alzheimer's disease.
Its distinctive research style is a "two-pronged" (nitoryu) approach, engaging in both biochemical research on nucleic acids and proteins and medical research on dementia.
The lab was established in April 2025.
Key terms
- DNA aptamer
- A chemically synthesized short single-stranded DNA that folds up and has a binding ability to interact strongly with specific molecules
- Amyloidogenic proteins
- Proteins that cause neurodegenerative diseases by aggregating abnormally
- Two-pronged approach (nitoryu)
- A research style that engages in both biochemical research on nucleic acids and proteins and medical research on dementia
NewsLab news
Lab tour registration is now open (tours held on Oct. 14 and Oct. 28)
A collaborative research paper with Associate Professor Tsukakoshi as corresponding author was published in Biochemical and Biophysical Research Communications
A paper from a collaborative study was published in ACS Sensors
ResearchResearch themes
This lab aims to open up new biochemical research through aptamer engineering and applications. In particular, it is pursuing research toward understanding the pathology of neurodegenerative diseases such as Alzheimer's disease, which cause dementia, and toward establishing treatment and diagnostic methods.
Development and applications of DNA aptamers
Short single-stranded DNA can fold into three-dimensional structures and interact strongly with specific molecules. DNA aptamers with this binding ability have advantages such as flexible molecular design and easy modification of active groups, and their application to diagnosis and treatment is attracting attention.
*Illustrative imageUnderstanding dementia pathology, and diagnosis and treatment
The lab aims to understand the pathology of neurodegenerative diseases such as Alzheimer's disease and to establish treatment and diagnostic methods. It also conducts basic research exploring the molecular pathology of the amyloidogenic proteins that cause these diseases, and works on aptamer development and the search for drug discovery targets.
MembersFaculty
The members of the Tsukakoshi Lab consist of faculty, and master's and undergraduate students.As of 2026
- Associate ProfessorKaori Tsukakoshi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Alzheimer's disease brain comparison” derivative work: Garrondo (talk) SEVERESLICE_HIGH.JPG: ADEAR: "Alzheimer's Disease Education and Referral Center, a service of the National Institute on Aging." PRECLINICALSLICE_HIGH.JPG: ADEAR: "Alzheimer's Disease Education and Referral Center, a service of the National Institute on Aging." / Public domain (cropped)
- Understanding dementia pathology, and diagnosis and treatment: “O'Donnell-Luria–Rodan syndrome — Brain MRI” Yang Li; Lijuan Fan; Rong Luo; Zuozhen Yang; Meng Yuan; Jinxiu Zhang; Jing Gan / CC BY 4.0 (cropped)
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