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Sakuma Lab
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The lab investigates the mechanisms by which muscle is lost with aging, and how to prevent it.
AboutAbout the lab
Elucidating the mechanisms of sarcopenia and developing preventive measures.
The Sakuma Lab studies sarcopenia, the loss of muscle mass that occurs with aging.
With an aging society in view, the lab aims to elucidate why muscle atrophy occurs.
It also explores effective ways to reduce it, such as exercise, supplements, and dietary content.
Autophagy, the cell's protein recycling system, is thought to fail with aging, causing unneeded proteins to accumulate inside skeletal muscle cells, which in turn leads to sarcopenia.
Key terms
- Sarcopenia
- A condition in which muscle mass decreases and strength declines with aging; also called age-related muscle weakening
- Autophagy
- A mechanism by which cells break down unneeded proteins within themselves and rebuild them as materials
- Skeletal muscle
- Muscle that attaches to bones and moves the body. It also supports the body and maintains posture
ResearchResearch themes
With an aging society in view, the lab aims to elucidate why muscle atrophy associated with aging (sarcopenia) occurs. In addition, it explores effective ways to reduce it, such as exercise, supplements, and dietary content.
*Illustrative imageWhy muscle grows less easily with age
Even with the same training, muscle becomes harder to build as people get older. The lab investigates the reason from the mechanisms inside muscle cells, and tries to clarify the pathway by which sarcopenia, the loss of muscle with aging, occurs.
*Illustrative imagePreventing muscle decline with diet and drugs
So that people can keep walking on their own feet and swallowing food even in old age, the lab is organizing methods for easing muscle decline through nutrition and drugs. It also investigates the relationship between sarcopenia and undernutrition or swallowing disorders.
MembersFaculty
The members of the Sakuma Lab consist of faculty members, doctoral students, research students, and visiting students.As of 2026
- ProfessorKunihiro SakumaPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Muskel ( 1)” Rollroboter / CC BY-SA 3.0 (cropped)
- Why muscle grows less easily with age: “Skeletal muscle histology” Veeresh likhitha / CC BY-SA 4.0 (cropped)
- Preventing muscle decline with diet and drugs: “Protein shake” Sandstein / CC BY 3.0 (cropped)
- Related lab (高橋研究室): “Morning meal with coffee yogurt bowl and water in a cozy cafe setting” Shixart1985 / CC BY 2.0 (cropped)
- Related lab (高松研究室): “Facial expressions - The Cartoonist's Art” J. Campbell Cory / Public domain (cropped)
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