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Matsumoto Lab
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The lab explores, at the molecular level, how radiation affects living organisms.

AboutAbout the lab
Linking the nucleus of the atom and the nucleus of the cell.
The Matsumoto Lab studies the effects of radiation on living organisms and the responses that organisms show to radiation.
The lab aims to understand these mechanisms at the molecular level, incorporating techniques from molecular biology and cell biology.
It seeks to connect its findings to next-generation radiation therapy and radiation protection based on individual radiosensitivity.
The lab aims to contribute to the safe and secure use of nuclear power and radiation, and to further improvement of radiation therapy for cancer.
Key terms
- DNA double-strand break
- Damage in which both strands of DNA are broken at the same time. A serious injury that can lead to cell death if left unrepaired
- DNA-PK
- A protein kinase that is activated by binding to the ends of double-stranded DNA. It acts as a sensor of breaks
- Protein phosphorylation
- A chemical reaction in which a phosphate group is attached to a protein. One of the mechanisms for transmitting signals inside cells
NewsLab news
The lab's findings on the effects of low-dose-rate radiation were published in a scientific journal
The lab's findings were published in J. Biol. Chem.
A master's student received the Kakuyukai Award (Master's Thesis Award), FY2025 (March)
A master's student received the Outstanding Student Award upon completion of the Nuclear Engineering Course
Prof. Matsumoto received the FY2024 Japan Radiation Research Society Award
ResearchResearch themes
The lab aims to understand, at the molecular level, how radiation acts on living organisms and how organisms respond to it. Using the question of how DNA damage is recognized and repaired as a starting point, it conducts research with applications to radiation therapy and radiation protection in view.
*Illustrative imageRecognition and Repair of DNA Double-Strand Breaks
DNA-PK, an enzyme that is activated by binding to the ends of double-stranded DNA, is thought to act as a sensor of DNA double-strand breaks. Using this molecule as a clue, the lab aims to elucidate how organisms respond to breaks and the mechanisms by which they are repaired.
*Illustrative imageEffects Determined in the First Three Minutes
The effects of radiation appear anywhere from days to decades later, but they are shaped by reactions such as protein phosphorylation that occur within minutes to hours after irradiation. The lab examines the reactions that occur about three minutes after irradiation in an attempt to predict future effects.
MembersFaculty
The members of the Matsumoto Lab consist of faculty members, postdoctoral researchers, doctoral, master's, and undergraduate students, and administrative assistants.As of 2025
- ProfessorYoshihisa MatsumotoPublications ↗
- Project Associate Professor宮川 隆
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Purple cells” National Cancer Institute / Public domain (cropped)
- Recognition and Repair of DNA Double-Strand Breaks: “20251019 Replica DNA double helix model Berlin 01” Flocci Nivis / CC BY 4.0 (cropped)
- Effects Determined in the First Three Minutes: “DNA double-strand break repair” Chaya5260 / CC BY-SA 4.0 (cropped)
- Related lab (Hayashizaki Lab): “CERN CCDTL LINAC 4 Prototype linear accelerator” Julian Herzog / CC BY-SA 3.0 (cropped)
- Related lab (Sagara Lab): “Nuclear Fuel Pellets ( )” Nuclear Regulatory Commission from US / Public domain (cropped)
- Related lab (Obara Lab): “Fast Flux Test Facility Reactor Core” ENERGY.GOV / Public domain (cropped)
- Related lab (Ishizuka Lab): “HFIR Refueling July )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
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