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Takinoue Lab
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The lab computes with molecules such as DNA to create materials that behave like living things.
AboutAbout the lab
Toward intelligent matter, woven from information, life, and physics.
The Takinoue Lab studies "intelligent matter" that behaves like a living organism.
Living systems can be thought of as molecular computers and molecular machines that move on their own using chemical energy.
By designing the higher-order structures of biomolecules and programming non-equilibrium biomolecular reactions, the lab aims to realize autonomously moving artificial cell systems and molecular artificial intelligence.
The lab is pioneering a field called "information-life physics," which combines life science, information science, physics, and engineering.
Key terms
- Molecular computing
- A new computing principle that uses molecules such as DNA themselves as the material and performs computation through chemical reactions
- Artificial cell
- A cell-like system assembled by hand, using lipid membranes or droplets to reproduce cell-like functions
- Soft matter
- A group of soft materials that easily change shape, such as gels, liquid crystals, and assemblies of biomolecules
NewsLab news
Succeeded in forming self-organized patterns of DNA droplets through molecular crowding
Research on light-driven DNA droplets featured in a university news article
A student received the Excellent Presentation Award at a research meeting of the Society for Chemistry and Micro-Nano Systems
A paper on controlling the physical properties of DNA phase-separated aggregates was published in ChemBioChem
A student received the Excellent Research and Presentation Award at the Saibonikusu Research Meeting
ResearchResearch themes
Now that materials science and information science have advanced greatly, science and technology that deal with "intelligent matter," which processes information like living things, will become essential. By combining fields such as life science, information science, physics, and engineering, the lab is pioneering a new scientific field that targets matter showing life-like intelligent behavior.
*Illustrative imageMolecular computing
The lab explores new computing principles that use "matter" itself, such as biomolecules like DNA and liquids, to compute at the nanoscale. Molecular computers compute by directly manipulating molecules according to the laws of physics and chemistry.
Building artificial cells
Using DNA, RNA, proteins, lipids, and other materials, the lab builds lipid-vesicle-type and coacervate-type artificial cells. By building artificial life systems that adapt to their environment and evolve, and cell-like molecular robots, it also aims at applications in medicine and the environment.
*Illustrative imageRobots that carry out experiments automatically
The lab aims to further develop experimental algorithms and robot systems that make use of AI technology, and to develop technology that autonomously produces molecular computers and artificial cells.
*Illustrative imagePhysics of intelligent soft matter
The lab explores phenomena in which soft matter spontaneously forms ordered structures and patterns in open non-equilibrium systems, where energy, matter, and information constantly flow in and out. It creates active matter with functions such as computation, memory, and autonomous motion, and elucidates the physical mechanisms behind them.
MembersFaculty
The Takinoue Lab consists of faculty members, postdoctoral researchers, doctoral, master's, and undergraduate students, administrative staff, technical staff, and collaborating researchers.As of 2026
- ProfessorMasahiro TakinouePublications ↗
- Assistant ProfessorJames Richard Archer
- Project Assistant ProfessorHirotake Udono
- Project Assistant ProfessorTomoya MaruyamaPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “2T7A4” Yma3591 / CC BY 4.0 (cropped)
- Molecular computing: “DNA Helix CPK” Ude / Public domain (cropped)
- Robots that carry out experiments automatically: “Robot arm handles an assay plate” National Institute of Allergy and Infectious Diseases / Public domain (cropped)
- Physics of intelligent soft matter: “Patterns in the Belousov–Zhabotinsky reaction” Philip Ball - courtesy of Michael C. Rogers and Stephen Morris, University of Toronto / CC BY 4.0 (cropped)
- Related lab (下坂研究室): “Warsaw city center in winter at night December 2023” Oleslawlama / CC BY-SA 4.0 (cropped)
- Related lab (吉瀬研究室): “Cray 1 IMG 9126” Rama / CC BY-SA 2.0 fr (cropped)
- Related lab (宮崎研究室): “CSC1941” Alexkisi / CC BY-SA 3.0 (cropped)
- Related lab (高安美佐子研究室): “Market centre in Tokyo stock exchange” ehnmark / CC BY 2.0 (cropped)
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