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Shimoyama Lab
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The lab designs processes for making pharmaceuticals and materials using supercritical carbon dioxide.
AboutAbout the lab
Changing how things are made with supercritical CO2.
The Shimoyama Lab studies chemical processes that use carbon dioxide in a supercritical state.
It takes advantage of three properties of supercritical CO2: its ability to dissolve substances well, to spread well, and to penetrate into narrow gaps.
The lab produces pharmaceutical crystals, lipid nanoparticles, and materials that capture carbon dioxide from the air.
It designs processes by combining computational prediction of phase equilibria with control of flow inside narrow channels.
Key terms
- Supercritical CO2
- Carbon dioxide at high temperature and pressure, where the distinction between gas and liquid disappears. It combines a strong ability to dissolve substances with a strong ability to spread.
- Phase equilibrium
- The settled state in which a mixture of substances has separated into phases such as gas and liquid. It is the foundation of process design.
- Microchannel
- A flow path as narrow as a human hair, in which mixing and flow can be finely controlled.
NewsLab news
A doctoral student received an award from the Global Fellows Programme
A student received the Jerry King Poster Award at ISSF2025
A doctoral student received a Poster Presentation Award at PDDS2024
Students received the Student Award and the Outstanding Student Award at the SCEJ Autumn Meeting
A student received a Student Poster Presentation Award at MTMS24
ResearchResearch themes
The lab designs new chemical processes in supercritical CO2 while predicting phenomena such as phase equilibria and fluid flow. Its work includes crystallization of pharmaceuticals, capturing carbon dioxide from the atmosphere, and forming fine particles used in cosmetics.
*Illustrative imagePredicting phase equilibria of supercritical CO2
The lab predicts phase equilibria in supercritical CO2 systems using molecular surface information from quantum chemical calculations together with statistical thermodynamics, and works on designing processes in which different phases mix. It is also designing reaction environments that combine in situ spectroscopic measurement with flow analysis.
*Illustrative imagePharmaceutical crystals and lipid nanoparticles
Using the solubility, diffusivity, and permeability of supercritical CO2, the lab develops processes to produce cocrystals of active pharmaceutical ingredients, CO2-driven crystals, and lipid nanoparticles.
*Illustrative imageCapturing CO2 from the air and air batteries
Toward CO2 adsorption and desorption processes that exploit the conversion of light into heat, the lab makes porous carbon adsorbents by supercritical drying. The same supercritical drying is also used to make porous carbon electrodes for metal-air batteries.
*Illustrative imageFine particles made in microchannels
The lab controls mixing and flow inside microchannels to build processes that continuously produce, within the flow, the emulsions and liposomes used in cosmetics. With LipTube, which combines supercritical CO2 and a microchannel, it controlled liposome size over a wide range.
MembersFaculty
The Shimoyama Lab consists of faculty members and students in the doctoral, master's, and undergraduate programs.As of 2025
- ProfessorYusuke ShimoyamaPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Critical carbon dioxide-3” Bernhard Kuemel、Regi51 / CC BY-SA 2.0 at (cropped)
- Predicting phase equilibria of supercritical CO2: “Supercritical Fluids Reactor” RHanush / CC BY-SA 4.0 (cropped)
- Pharmaceutical crystals and lipid nanoparticles: “Double emulsion droplets” Catrin Sohrabi / CC BY-SA 4.0 (cropped)
- Capturing CO2 from the air and air batteries: “Brick of aerogel” Courtesy NASA/JPL-Caltech / Public domain (cropped)
- Fine particles made in microchannels: “Hydrodynamic flow focusing in a microfluidic device” Ihor Panas / CC BY 4.0 (cropped)
- Related lab (Fukushima-Shoji Lab): “Emerging geometry in life building blocks” FedeCaimi / CC BY 4.0 (cropped)
- Related lab (Mori Lab): “Glow discharge regions” Derived file: Chetvorno Original file: Jannis Andrija Schnitzer / CC BY-SA 2.0 (cropped)
- Related lab (Aoki Lab): “Rolling-element bearing 60 mm” Massimiliano Lincetto / CC BY-SA 3.0 (cropped)
- Related lab (Yoshikawa Lab): “Disc Tube module disc with octagonal membrane cushion” Adrian.barna / CC BY-SA 4.0 (cropped)
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