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Park Lab
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The lab explores the origin of life and the mechanisms of immunity through nucleic acid chemistry.
AboutAbout the lab
Designing the mechanisms of life with the principles of chemistry.
The Park Lab studies how nucleic acid chemistry relates to the origin of life, molecular recognition, and the regulation of immunity.
Combining organic chemistry, chemical biology, and immunology, the lab designs and synthesizes molecules with functions based on nucleic acids.
Using these molecules, the lab aims to visualize and control the molecular workings behind the processes of life.
The lab is also interested in nucleic acid catalysts that serve as models of primitive enzymes, and in nucleic acids with unusual structures such as Z-DNA.
Key terms
- Nucleic acid
- A general term for DNA and RNA. Molecules that carry genetic information, in which bases are linked together like a chain.
- Aptamer
- A short nucleic acid or similar molecule selected to bind strongly to a specific target molecule.
- Z-DNA
- A form of DNA that takes a left-handed helix, in contrast to the right-handed helix of ordinary DNA.
ResearchResearch themes
The lab creates molecules with nucleic acid-based functions in order to observe, control, and utilize the processes of life. By bridging molecular-level chemistry and complex chemical systems, it aims to clarify the complexity of life and the chemical principles behind the origin and evolution of life.
*Illustrative imageNucleic Acid-Based Molecular Assemblies
By combining the building blocks of living things, such as nucleic acids, amino acids, and fatty acids, the lab creates molecular assemblies that function as next-generation aptamers and as mechanisms for regulating immunity.
*Illustrative imageCatalysts Made from DNA and Metals
The lab creates catalysts that combine DNA and metals, and investigates how the structure of DNA contributes to the reactions. It also explores the possibility that such complexes acted as catalysts before enzymes emerged.
*Illustrative imageSeeing Structural Changes with Fluorescent Nucleic Acids
The lab designs and synthesizes fluorescent nucleic acid building blocks that retain the ability of bases to form pairs, and uses them to study the structures of nucleic acids, such as left-handed Z-DNA and Z-RNA, and the transitions between them.
MembersFaculty
- Associate ProfessorSoyoung Park
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “A-B-Z-DNA Side View” Thorwald / Public domain (cropped)
- Nucleic Acid-Based Molecular Assemblies: “Spinach (RNA)” Huang, H., Suslov, N.B., Li, N.S., Shelke, S.A., Evans, M.E., Koldobskaya, Y., Rice, P.A., Piccirilli, J.A. / CC BY-SA 3.0 (cropped)
- Catalysts Made from DNA and Metals: “DNA Orbit Animated Clean” Circli / CC BY-SA 4.0 (cropped)
- Seeing Structural Changes with Fluorescent Nucleic Acids: “FluorescenceMicroscopeSample HerringSpermSYBRGreen” Zephyris / CC BY-SA 3.0 (cropped)
- Related lab (Aoki Lab): “Rolling-element bearing 60 mm” Massimiliano Lincetto / CC BY-SA 3.0 (cropped)
- Related lab (Yamamoto-Imaoka Lab): “Platinum nanoparticles” PieroSpeleo / CC BY-SA 4.0 (cropped)
- Related lab (Serizawa-Sawada Lab): “Paper. Magnification power 2000x. 01” Nobody16w / CC BY-SA 4.0 (cropped)
- Related lab (Nakamura Lab): “Chimney-hires” NOAA Vents Program / Public domain (cropped)
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