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Hayashi Lab
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A lab that examines, at the molecular level, what happens on the surfaces of materials that are compatible with the body.
AboutAbout the lab
What is happening on a material's surface right now?
The Hayashi Lab studies molecular-level events at “biointerfaces,” where artificial materials meet the body.
Whether materials such as contact lenses, artificial joints, and catheters are compatible with the body is determined by what water, proteins, and cells do within just a few nanometers of the surface.
The lab “sees” and understands what happens there using measurement methods it develops itself, and connects this understanding to the design of new biomaterials.
Members from many different countries carry out research while discussing it daily in English and Japanese.
Key terms
- Biocompatibility
- The property of a material being accepted by the body, rather than rejected, when it comes into contact with it.
- Self-assembled monolayer
- A film in which molecules line up spontaneously and cover a surface with a single layer. It is used as a model for studying surface properties.
- Atomic force microscope
- A microscope that traces a surface with a fine needle to measure atomic-scale bumps and forces.
NewsLab news
A paper on hydration water in hydrogels was accepted
A paper on protein adsorption onto sugar-based monolayers was accepted
A paper on the protein layer formed on antifouling surfaces was accepted
A paper on the wall of water on monolayer surfaces was accepted
A paper on the mechanical properties and hydration of zwitterionic peptide films was accepted
ResearchResearch themes
The lab uses measurement methods it develops itself to observe and understand molecular-level events at the interface where materials meet the body. The knowledge gained is applied to the design of new biomaterials.
*Illustrative imageInterfacial Water Determines Biocompatibility
Why do proteins not attach to some surfaces? Using self-assembled monolayers as models, the lab examines the hydrogen-bond structure of water on zwitterionic and oligo(ethylene glycol) surfaces, clarifying at the molecular level how antifouling properties arise.
*Illustrative imageCreating Measurement Methods That Exist Nowhere Else
Interfacial water and adsorbed proteins cannot be seen with commercial instruments alone. The lab improves and develops atomic force microscopy, single-molecule force spectroscopy, infrared spectroscopy, QCM-D, SPR, and other methods on its own, so members gain experience not only in using instruments but in building them.
*Illustrative imageSearching for Materials with Data Science and AI
Using multivariate spectral decomposition and machine learning, the lab extracts hidden information from complex measurement data. It also works on searching for biomaterials by combining AI with automated experiments.
*Illustrative imageResearch Connected to Society
With medical applications in mind, the lab also conducts joint research with companies. It aims to connect the understanding gained from basic research to materials and devices that are actually used.
MembersFaculty
The members of the Hayashi Lab are faculty, administrative staff, and doctoral and master's students.As of 2026
- Associate ProfessorTomohiro HayashiPublications ↗
VoicesStudent voices
Compiled from answers by students who were in the lab. Ratings and reviews reflect individual students' experiences, not the lab's official views.
Students who take part in an interview may receive a thank-you gift worth ¥1,000, regardless of what they say.
On a 4-point scale, ● marks where students' answers fall
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Corrective soft contact lenses, with high oxigen permeability” Albarubescens / CC BY-SA 4.0 (cropped)
- Interfacial Water Determines Biocompatibility: “Water droplet on a 5 grains of hydrophobic sand” Aidar.Seralin / CC BY-SA 4.0 (cropped)
- Creating Measurement Methods That Exist Nowhere Else: “Atomic Force Microscope ( )” National Institute of Standards and Technology / Public domain (cropped)
- Searching for Materials with Data Science and AI: “BioMek FX P200 96 liquid handling robot” National Institute of Allergy and Infectious Diseases (NIAID) / Public domain (cropped)
- Research Connected to Society: “Stent1 (fcm)” Frank C. Müller / CC BY-SA 4.0 (cropped)
- Related lab (中辻研究室): “Atomic resolution Au100” Erwinrossen / Public domain (cropped)
- Related lab (中島・磯部研究室): “Kutani-Style Arita-Ware, 17th century, Japan, porcelain - Art Institute of Chicago - DSC00212” Daderot / CC0 (cropped)
- Related lab (三宮研究室): “Gold Colloid of varying size” Kumarbarc / CC BY-SA 4.0 (cropped)
- Related lab (鎌田研究室): “Perovskite-Magnetite-207500” Robert M. Lavinsky / CC BY-SA 3.0 (cropped)
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