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Nutrition and Metabolic Medicine Lab
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A lab that studies health from the fetal period onward through nutrition and gut bacteria.
AboutAbout the lab
Food shapes the body and health.
The Nutrition and Metabolic Medicine Lab studies how diet affects human health, with nutrition and metabolism as keywords.
Using birth cohort studies that begin with mothers during pregnancy, the lab examines the relationship among nutrition, the gut environment, and health from the fetal period.
In collaboration with Chiba University Hospital, it also conducts research in clinical nutrition, which supports treatment from the nutritional side.
Key terms
- Birth cohort
- A study that follows children and parents from pregnancy or birth, and the group of participants in it
- Gut microbiota
- The community of many bacteria living in the intestine, which is influenced by diet and related to health
- DNA methylation
- The attachment of small tags (methyl groups) to DNA, which is involved in switching genes on and off
- DOHaD theory
- The idea that the environment during the fetal period and soon after birth affects susceptibility to disease in adulthood
ResearchResearch themes
With nutrition and metabolism as keywords, the lab studies how diet and gut bacteria relate to human health. In addition to using the birth cohort study of the Center for Preventive Medical Sciences to examine the relationship among nutrition, the gut environment, and health, it conducts clinical nutrition research in cooperation with the university hospital.
*Illustrative imageGut bacteria and the health of mothers and children
The lab examines how the gut microbiota of mothers during pregnancy and of their newborn children affect the health of both. It has reported that the mother's gut microbiota influences fetal growth and predisposition to allergy, and is now tracking how the child's gut microbiota develops.
*Illustrative imageFetal environment and DNA methylation
The lab focuses on DNA methylation as a mechanism by which the environment during pregnancy affects a child's health. Using the umbilical cord, which consists only of fetal cells, it examines the relationship with the mother's weight gain and nutritional status during pregnancy.
*Illustrative imageDNA methylation and adipocytes
Focusing on the H19 gene, which functions in adipocytes (fat cells), the lab studies the relationship between its DNA methylation and adipocyte function from the perspective of the DOHaD theory.
*Illustrative imageClinical nutrition research
In cooperation with the Department of Clinical Nutrition at Chiba University Hospital, the lab conducts research that supports treatment from the nutritional side. In ovarian cancer, it showed that poor nutritional status before chemotherapy leads to more treatment interruptions.
MembersFaculty
The Nutrition and Metabolic Medicine Lab's members consist of faculty, researchers, and doctoral and master's students.As of 2026
- ProfessorKenichi Sakurai
- Associate ProfessorMasaya Koshizaka
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “CSIRO ScienceImage 4333 Human nutrition research” division, CSIRO / CC BY 3.0 (cropped)
- Gut bacteria and the health of mothers and children: “Pregnant woman holds white babygrow sleeper” Petr Kratochvil (https://publicdomainpictures.net/en/browse-author.php?a=1) / CC0 (cropped)
- Fetal environment and DNA methylation: “E.T. The Umbilical Cord ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- DNA methylation and adipocytes: “DNA Double Helix by NHGRI” National Human Genome Research Institute / Public domain (cropped)
- Clinical nutrition research: “Hospital meal in Israel” Nizzan Cohen / CC BY 4.0 (cropped)
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